Martí-Bonmatí L, Talens A, del Olmo J, de Val A, Serra M A, Rodrigo J M, Ferrández A, Torres V, Rayón M, Vilar J S
Department of Diagnostic Radiology, Hospital Dr Peset, Valencia, Spain.
Radiology. 1993 Jul;188(1):37-43. doi: 10.1148/radiology.188.1.8511317.
To characterize the relationship between findings on magnetic resonance (MR) images and histologic changes in chronic liver disease, a prospective study was performed in 100 patients with chronic hepatitis and cirrhosis and 28 healthy subjects. Biopsy specimens, obtained in all patients before MR imaging, were evaluated with the histologic activity (HA) index; MR images were obtained with short inversion time inversion-recovery (STIR) and spin-echo sequences. On STIR images, normal livers were iso-intense to fat. Significant differences (P < .001) existed between signal intensity of normal livers and that of diseased livers, which were brighter than normal livers on STIR images. The ratio of signal intensity of liver to that of fat on STIR images was associated with an HA index grouped by severity (P < .05): Patients with higher HA scores had a brighter liver. Signal intensity ratios on MR images were statistically significantly associated with periportal and lobular necrosis and portal inflammation. The signal intensity of liver on STIR images is associated with the degree of histologic severity in patients with chronic liver disease.
为了描述磁共振（MR）图像表现与慢性肝病组织学变化之间的关系，对100例慢性肝炎和肝硬化患者及28名健康受试者进行了一项前瞻性研究。在所有患者进行MR成像之前获取活检标本，并根据组织学活动（HA）指数进行评估；采用短反转时间反转恢复（STIR）序列和自旋回波序列获取MR图像。在STIR图像上，正常肝脏与脂肪呈等信号。正常肝脏与病变肝脏的信号强度存在显著差异（P < 0.001），病变肝脏在STIR图像上比正常肝脏更亮。STIR图像上肝脏与脂肪的信号强度比与按严重程度分组的HA指数相关（P < 0.05）：HA评分较高的患者肝脏更亮。MR图像上的信号强度比与汇管区和小叶坏死以及门脉炎症在统计学上显著相关。STIR图像上肝脏的信号强度与慢性肝病患者的组织学严重程度相关。
