Prisco D
Clinica Medica I, Università degli Studi di Firenze.
Ric Clin Lab. 1990 Oct-Dec;20(4):217-25. doi: 10.1007/BF02900706.
Blood clotting activation causes an increased thrombin generation. The direct measurement of plasma thrombin is not feasible due to the absence of reliable methods. Thus, only indirect approaches are possible. Different markers of thrombin generation have been proposed in the past years. Some methods are nowadays of historical interest. Among various methods reported the 'gold standard' is fibrinopeptide A assay, while thrombin-antithrombin complexes assay needs further validation to be employed as a reliable index of increased thrombin generation, and more recent methods (such as those for F1+2 fragment and for protein C activation peptide) are not available for routine use.
血液凝固激活会导致凝血酶生成增加。由于缺乏可靠的方法，直接测量血浆凝血酶并不可行。因此，只能采用间接方法。在过去几年中，已经提出了不同的凝血酶生成标志物。如今，有些方法只具有历史意义。在报道的各种方法中，“金标准”是纤维蛋白肽A测定法，而凝血酶-抗凝血酶复合物测定法需要进一步验证才能作为凝血酶生成增加的可靠指标，并且更新的方法（如F1+2片段和蛋白C激活肽的测定方法）尚不能用于常规检测。
