Awadzi K, Schulz-Key H, Edwards G, Breckenridge A, Orme M, Gilles H
Onchocerciasis Chemotherapeutic Research Centre, Hohoe Hospital, Ghana.
Trop Med Parasitol. 1990 Dec;41(4):383-6.
Twenty patients from an area of vector control in the savannah region of northern Ghana with moderate to heavy infection with Onchocerca volvulus were randomised to receive two priming doses of levamisole 150 mg on two occasions followed either by mebendazole-citrate (500 mg) given daily or twice daily for 14 days. The two dose levels produced a similar effect on skin microfilariae (80-88% reduction) with a very mild systemic clinical reaction: low levels were maintained over 42 weeks. Both regimes were embryotoxic for O. volvulus; an effect which was transient in the single dose group but persisted for more than three months in the twice daily dose group. Mebendazole-citrate appeared to be absorbed more predictably than has been observed previously for mebendazole. The degree of systemic exposure as determined by measurement of AUC (0-24 h) was 2.5 times greater for the twice daily dose as compared to the single dose and this fact was reflected in the efficacy of the two dose regimes against the adult female worms at three months.
来自加纳北部萨凡纳地区一个病媒控制区的20名盘尾丝虫中度至重度感染患者被随机分组，接受两次150毫克左旋咪唑的起始剂量，分两次给药，随后每日或每日两次给予柠檬酸甲苯咪唑（500毫克），持续14天。这两种剂量水平对皮肤微丝蚴产生了相似的效果（减少80 - 88%），全身临床反应非常轻微：在42周内维持在低水平。两种治疗方案对盘尾丝虫均有胚胎毒性；单剂量组的这种作用是短暂的，但每日两次剂量组持续了三个多月。柠檬酸甲苯咪唑的吸收似乎比以前观察到的甲苯咪唑更可预测。通过测量AUC（0 - 24小时）确定的全身暴露程度，每日两次剂量组是单剂量组的2.5倍，这一事实反映在两种剂量方案在三个月时对成年雌虫的疗效上。
