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锌离子对肝脏果糖1,6 - 二磷酸酶活性的抑制作用:咪唑丙酮酸的逆转作用

Inhibition of liver fructose 1,6-bisphosphatase activity by Zn2+: reversal by imidazole pyruvate.

作者信息

Han P F, Han G Y, Cole T W, Owen G S, Johnson J

出版信息

Experientia. 1978 Jun 15;34(6):704-5. doi: 10.1007/BF01947270.

DOI:10.1007/BF01947270
PMID:207556
Abstract

Imidazole pyruvate was found to be a very potent natural chelating agent in reversing the inhibition of liver fructose 1,6-bisphosphatase activity by Zn2+. This metabolite may play a physiological role in gluconeogenesis.

摘要

咪唑丙酮酸被发现是一种非常有效的天然螯合剂,可逆转锌离子对肝脏果糖1,6 -二磷酸酶活性的抑制作用。这种代谢产物可能在糖异生过程中发挥生理作用。

相似文献

1
Inhibition of liver fructose 1,6-bisphosphatase activity by Zn2+: reversal by imidazole pyruvate.锌离子对肝脏果糖1,6 - 二磷酸酶活性的抑制作用:咪唑丙酮酸的逆转作用
Experientia. 1978 Jun 15;34(6):704-5. doi: 10.1007/BF01947270.
2
Dual role of Zn2+ as inhibitor and activator of fructose 1,6-bisphosphatase of rat liver.锌离子作为大鼠肝脏果糖1,6 - 二磷酸酶抑制剂和激活剂的双重作用。
Proc Natl Acad Sci U S A. 1976 Aug;73(8):2692-5. doi: 10.1073/pnas.73.8.2692.
3
Effect of substrate and AMP on the reversal of Zn2+ inhibition of turkey liver fructose-1,6-bidphosphatase by chelators.底物和AMP对螯合剂逆转Zn2+对火鸡肝脏果糖-1,6-二磷酸酶抑制作用的影响。
Biochem Biophys Res Commun. 1980 Mar 28;93(2):558-65. doi: 10.1016/0006-291x(80)91113-4.
4
Activation of rabbit muscle fructose 1,6-bisphosphatase by histidine and carnosine.
J Biochem. 1980 Jan;87(1):179-85. doi: 10.1093/oxfordjournals.jbchem.a132723.
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Binding of Zn2+ to rabbit muscle fructose 1,6-bisphosphatase and its effect on the catalytic properties.
Arch Biochem Biophys. 1979 May;194(2):481-5. doi: 10.1016/0003-9861(79)90642-8.
6
The effect of Zn2+ on the inhibition of Fru-P2ase by AMP.锌离子(Zn2+)对AMP抑制果糖二磷酸酶(Fru-P2ase)的影响。
Biochem Biophys Res Commun. 1979 May 28;88(2):656-60. doi: 10.1016/0006-291x(79)92098-9.
7
Proceedings: Structural modifications of fructose 1,6-bisphosphatase and its regulation by histidine under gluconeogenic conditions.会议论文:在糖异生条件下果糖1,6 -二磷酸酶的结构修饰及其受组氨酸的调控
Ital J Biochem. 1974 Jul-Aug;23(4):264-5.
8
Fructose 1,6-bisphosphatase in rat liver cytosol: interactions between the effects of K+, Zn2+, Mn2+, and fructose 2,6-bisphosphate as measured in a steady-state assay.大鼠肝细胞溶胶中的果糖1,6-二磷酸酶:在稳态测定中所测得的K⁺、Zn²⁺、Mn²⁺和果糖2,6-二磷酸的效应之间的相互作用
Arch Biochem Biophys. 1983 Jun;223(2):572-83. doi: 10.1016/0003-9861(83)90622-7.
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Regulation of fructose, 1,6-bisphosphatase by histidine under gluconeogenic conditions.在糖异生条件下,组氨酸对果糖-1,6-二磷酸酶的调节作用。
Proc Natl Acad Sci U S A. 1974 Jun;71(6):2166-8. doi: 10.1073/pnas.71.6.2166.
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Modification of brain fructose-1,6-bisphosphatase activity by chelators: "induction" of 5'-AMP sensitivity.螯合剂对脑果糖-1,6-二磷酸酶活性的修饰:5'-AMP敏感性的“诱导”
Biochem Biophys Res Commun. 1986 Sep 14;139(2):571-80. doi: 10.1016/s0006-291x(86)80029-8.

引用本文的文献

1
Parenteral zinc and tissue metallothionein in normal and diabetic rats.静脉内给予锌和组织金属硫蛋白在正常和糖尿病大鼠中的作用。
Biol Trace Elem Res. 1986 Dec;11(1):147-59. doi: 10.1007/BF02795531.

本文引用的文献

1
Determination of the tautomeric form of the imidazole ring of L-histidine in basic solution by carbon-13 magnetic resonance spectroscopy.用碳-13磁共振波谱法测定碱性溶液中L-组氨酸咪唑环的互变异构形式。
J Am Chem Soc. 1973 Jan 24;95(2):328-31. doi: 10.1021/ja00783a006.
2
Regulation of fructose, 1,6-bisphosphatase by histidine under gluconeogenic conditions.在糖异生条件下,组氨酸对果糖-1,6-二磷酸酶的调节作用。
Proc Natl Acad Sci U S A. 1974 Jun;71(6):2166-8. doi: 10.1073/pnas.71.6.2166.
3
The purification of fructose 1,6-diphosphatase from ox liver and its activation by ethylenediaminetetra-acetate.
从牛肝中纯化1,6-二磷酸果糖酶及其被乙二胺四乙酸激活。
Biochem J. 1975 Feb;145(2):323-34. doi: 10.1042/bj1450323.
4
Binding of Zn2+ to rat liver fructose-1,6-bisphosphatase and its effect on the catalytic properties.锌离子与大鼠肝脏果糖-1,6-二磷酸酶的结合及其对催化特性的影响。
Proc Natl Acad Sci U S A. 1977 Jul;74(7):2742-5. doi: 10.1073/pnas.74.7.2742.
5
Chicken liver fructose 1,6-bisphosphatase:purfication and some properties.
Arch Biochem Biophys. 1976 Mar;173(1):293-300. doi: 10.1016/0003-9861(76)90262-9.