在糖异生条件下，组氨酸对果糖-1,6-二磷酸酶的调节作用。
Regulation of fructose, 1,6-bisphosphatase by histidine under gluconeogenic conditions.
作者信息
Pontremoli S, Melloni E, De Flora A, Horecker B L
出版信息
Proc Natl Acad Sci U S A. 1974 Jun;71(6):2166-8. doi: 10.1073/pnas.71.6.2166.
Abstract
Fructose 1,6-bisphosphatase (EC 3.1.3.11) requires a free divalent metal and a metal chelate for optimum activity in the neutral pH range. The latter requirement can be satisfied by histidine, which appears to function as the chelating metabolite in vivo. Under fasting conditions, the concentrations of histidine in rabbit liver vary in the range required for activation of fructose bisphosphatase, and the enzyme itself is modified so that it becomes more responsive to histidine.
摘要
果糖1,6 -二磷酸酶（EC 3.1.3.11）在中性pH范围内需要一种游离的二价金属和一种金属螯合物来达到最佳活性。后一需求可由组氨酸满足，组氨酸在体内似乎作为螯合代谢物发挥作用。在禁食条件下，兔肝脏中组氨酸的浓度在激活果糖二磷酸酶所需的范围内变化，并且该酶自身会发生修饰，从而使其对组氨酸更敏感。
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本文引用的文献
1
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Biochem J. 1965 Feb;94(2):436-45. doi: 10.1042/bj0940436.
2
RECIPROCAL EFFECTS OF CARBON SOURCES ON THE LEVELS OF AN AMP-SENSITIVE FRUCTOSE-1,6-DIPHOSPHATASE AND PHOSPHOFRUCTOKINASE IN YEAST.碳源对酵母中一种AMP敏感型果糖-1,6-二磷酸酶和磷酸果糖激酶水平的相互影响
Biochem Biophys Res Commun. 1965 Jun 18;20:15-20. doi: 10.1016/0006-291x(65)90944-7.
3
RENAL D-FRUCTOSE 1,6-DIPHOSPHATASE.肾D-果糖1,6-二磷酸酶
J Biol Chem. 1963 Nov;238:3528-34.
4
Studies on the free amino acids and related compounds in the tissues of the cat.猫组织中游离氨基酸及相关化合物的研究。
J Biol Chem. 1954 Dec;211(2):927-39.
5
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Biochem J. 1968 Apr;107(3):411-5. doi: 10.1042/bj1070411.
6
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7
The role of tryptophan in neutral fructose diphosphatase.
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8
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