Kravtsov A N, Ziuzina V P, Tynianova V I
Zh Mikrobiol Epidemiol Immunobiol. 1990 Oct(10):19-24.
Y. pestis, the causative agents of plague, have been found to be incapable of using heme iron bound to haptoglobin and hemopexin complexes in human blood and blood serum, and protein components of the serum are not the factors inhibiting this process. At the same time iron of free hemoglobin can be successfully utilized by Y. pestis in the systems used in this study. On the contrary, hemin not only produces any stimulating effect on the growth of Y. pestis in blood serum, but leads to the death of these bacteria [correction of lasteria].
鼠疫耶尔森菌作为鼠疫的病原体,已被发现无法利用与人类血液和血清中的触珠蛋白和血红素结合蛋白复合物结合的血红素铁,且血清中的蛋白质成分并非抑制该过程的因素。与此同时,在本研究使用的系统中,鼠疫耶尔森菌能够成功利用游离血红蛋白中的铁。相反,血红素不仅不会对鼠疫耶尔森菌在血清中的生长产生任何刺激作用,反而会导致这些细菌死亡[拉斯特里亚的校正] 。