Lebedeva R N, Bondarenko A V, Abbakumov V V, Nikoda V V, Borisova I V, Karavaev B I, Klimova E I
Anesteziol Reanimatol. 1989 Sep-Oct(5):50-4.
Tramal was given to 204 patients who were operated on the lung, heart, abdomen. During pain therapy, good and satisfactory results were on average obtained in 75% patients operated on the lung, in 77%, on the heart, in 89%, on the abdomen, in 70%, on the great vessels. The absence of the inhibitory effect of the drug on the respiratory center and its slightly marked sedative effect allow one to recommend the agent for application in the early period following the surgery when narcotic analgesics still retain their effect and a real risk of their overdosage exists. During prolonged artificial pulmonary ventilation in the early postoperative period and in impaired adaptation of the patients to a respirator, tramal aids normalization of lung mechanics and hemodynamic parameters without eliminating and suppressing the patients' consciousness and results in cessation of muscular shivering. Adverse effects of tramal are of no decisive clinical significance and occur mainly when the drug is rapidly injected into the vein.
曲马多用于204例接受肺部、心脏、腹部手术的患者。在疼痛治疗过程中，接受肺部手术的患者平均75%取得良好和满意效果，心脏手术患者为77%，腹部手术患者为89%，大血管手术患者为70%。该药物对呼吸中枢无抑制作用，且镇静作用轻微，这使得它适合在术后早期使用，此时麻醉性镇痛药仍有作用且存在过量使用的实际风险。在术后早期长时间人工肺通气以及患者对呼吸机适应不良的情况下，曲马多有助于肺力学和血流动力学参数正常化，且不会消除和抑制患者意识，还能使肌肉颤抖停止。曲马多的不良反应无决定性临床意义，主要在药物快速静脉注射时出现。
