Drago F, Valerio C, Clementi G, Scapagnini U
Funct Neurol. 1986 Oct-Dec;1(4):529-32.
D,L-allylglycine-induced seizures in rats were antagonized by flunarizine and other antiepileptic drugs. In this respect, the spectrum of flunarizine appears to be similar to that of diphenylhydantoin. A behavioral analysis of the effects of various drugs on amygdaloid kindled rats showed that flunarizine exerts anticonvulsive effects in this model with an ED50 of 42.8 mg/kg. Furthermore, flunarizine (1, 5, 25 and 50 mg/kg i.p.) reduced seizure parameters in rats injected with strychnine or pentetrazol. In this case, flunarizine reduced seizure intensity and increased the percentage of survival. In another study on genetically epileptic beagles, flunarizine significantly affected the REM and deep slow-wave sleep latencies.
氟桂利嗪和其他抗癫痫药物可拮抗D，L-烯丙基甘氨酸诱发的大鼠癫痫发作。在这方面，氟桂利嗪的作用谱似乎与苯妥英相似。对各种药物对杏仁核点燃大鼠影响的行为分析表明，氟桂利嗪在该模型中发挥抗惊厥作用，半数有效剂量为42.8mg/kg。此外，氟桂利嗪（腹腔注射1、5、25和50mg/kg）可降低注射士的宁或戊四氮的大鼠的癫痫发作参数。在这种情况下，氟桂利嗪降低了癫痫发作强度并提高了存活率。在另一项针对遗传性癫痫比格犬的研究中，氟桂利嗪显著影响快速眼动睡眠和深度慢波睡眠潜伏期。
