Qie W X
First Affiliated Hospital, Kunming Medical College.
Zhonghua Er Bi Yan Hou Ke Za Zhi. 1990 Aug;25(4):195-8, 254.
The ototoxicity of cisplatin and a comparison of the ototoxicity between cisplatin and kanamycin had been studied by morphological and biochemical methods. The results showed that the ototoxic effects of both drugs were similar, mainly affecting the cochlea, and next the vestibule. Lesions developed from the periphery to the center. The stria vascularis, the spiral ligament and the secretory epithelium of the vestibule were slightly injured by cis-platin. The K+ and Na+ concentrations of cochlear perilymph changed after the administration of both drugs. The ototoxicity of cis-platin appeared to be accumulated. So, while using cisplatin clinically, we stress the need for careful monitoring of the cochlear and vestibular functions.
通过形态学和生物化学方法研究了顺铂的耳毒性以及顺铂与卡那霉素耳毒性的比较。结果表明，两种药物的耳毒性作用相似，主要影响耳蜗，其次是前庭。病变从外周向中心发展。顺铂对血管纹、螺旋韧带和前庭分泌上皮有轻微损伤。两种药物给药后，耳蜗外淋巴中的钾离子和钠离子浓度均发生变化。顺铂的耳毒性似乎具有累积性。因此，在临床使用顺铂时，我们强调需要仔细监测耳蜗和前庭功能。
