Li L
First Affiliated Hospital, Bethune University of Medical Sciences, Changchun.
Zhonghua Er Bi Yan Hou Ke Za Zhi. 1990 Aug;25(4):205-7, 254.
Cisplatinum is a potent antineoplastic agent. Ototoxicity is one of the most prominent side effects. This paper reports characteristics of cisplatinum ototoxicity experiments showed that cisplatinum had ototoxic effects, both on hair cells and spiral ganglion neurons. The ototoxicity effect on hair cells and spiral ganglion neurons was demonstrated in the study. The inhibition of protein synthesis and metabolism may be responsible for its ototoxicity. The ototoxicity is progressive. Administration of large dose produces ototoxicity more easily.
顺铂是一种强效抗肿瘤药物。耳毒性是其最突出的副作用之一。本文报道了顺铂耳毒性的特征。实验表明，顺铂对毛细胞和螺旋神经节神经元均有耳毒性作用。该研究证实了顺铂对毛细胞和螺旋神经节神经元的耳毒性作用。蛋白质合成和代谢的抑制可能是其耳毒性的原因。耳毒性是渐进性的。大剂量给药更容易产生耳毒性。
