Kondo Y, Imai Y, Kubota Y, Hojo H, Nozoe S
Pharmaceutical Institute, Tohoku University, Sendai, Japan.
Chem Pharm Bull (Tokyo). 1990 Oct;38(10):2887-9. doi: 10.1248/cpb.38.2887.
Three bisbenzylisoqinoline alkaloids, chondocurine (Chon), berbamine (Ber), and cycleanine (Cyc) were tested for their protective effect on the quick death of mice primed with bacillus Calmette Guerin (BCG) and elicited with lipopolysaccharide (LPS). Seven-consecutive treatments with Chon or Cyc at a dose of 10 mg/kg following BCG priming resulted in significant improvement in the survival rate. A single dose of Chon also protected the BCG/LPS-treated mice from death if it was given immediately after, not 4 h after, LPS elicitation. These data show that bisbenzylisoquinoline alkaloids can protect mice from the lethal toxicity induced by the BCG/LPS combination treatment by inhibiting the priming with BCG or the elicitation with LPS.
对三种双苄基异喹啉生物碱，即chondocurine（Chon）、小檗胺（Ber）和环轮宁（Cyc），测试了它们对用卡介苗（BCG）致敏并用脂多糖（LPS）激发的小鼠快速死亡的保护作用。在BCG致敏后，以10 mg/kg的剂量连续七次给予Chon或Cyc，存活率显著提高。如果在LPS激发后立即而非4小时后给予单剂量的Chon，也可保护经BCG/LPS处理的小鼠免于死亡。这些数据表明，双苄基异喹啉生物碱可通过抑制BCG致敏或LPS激发，保护小鼠免受BCG/LPS联合处理诱导的致死毒性。
