Kondo Y, Imai Y, Hojo H, Hashimoto Y, Nozoe S
Pharmaceutical Institute, Tohoku University, Sendai, Japan.
Int J Immunopharmacol. 1992 Oct;14(7):1181-6. doi: 10.1016/0192-0561(92)90053-n.
The bisbenzylisoquinoline (BBI) alkaloids, chondocurine, tetrandrine, isotetrandrine and cepharanthine, were tested for immunosuppressive activity in mice. A plaque-forming cell (PFC) response to a T-cell-dependent antigen, sheep red blood cell, was significantly suppressed by a 7 day treatment of chondocurine or tetrandrine at 1 mg/kg/day and of isotetrandrine at 50 mg/kg/day, but not suppressed by cepharanthine treatment. The suppressive effect of chondocurine was greater when it was given after immunization rather than before or concurrently. However, it did not affect the PFC response to a T-cell-independent antigen, lipopolysaccharide. A delayed-type hypersensitivity was also suppressed by chondocurine treatment. There was no significant change in lymphocyte number and proportion of T-cell subsets in the BBI alkaloid-treated mice. These data suggest that there is selective inhibition by chondocurine and tetrandrine of the T-cell-dependent immune reactions.
对双苄基异喹啉（BBI）生物碱、chondocurine、粉防己碱、异粉防己碱和汉防己甲素进行了小鼠免疫抑制活性测试。对T细胞依赖性抗原绵羊红细胞的空斑形成细胞（PFC）反应，在以1 mg/kg/天的剂量用chondocurine或粉防己碱处理7天以及以50 mg/kg/天的剂量用异粉防己碱处理7天后受到显著抑制，但汉防己甲素处理未产生抑制作用。chondocurine在免疫后给药时的抑制作用比在免疫前或同时给药时更强。然而，它并不影响对T细胞非依赖性抗原脂多糖的PFC反应。迟发型超敏反应也受到chondocurine处理的抑制。在接受BBI生物碱处理的小鼠中，淋巴细胞数量和T细胞亚群比例没有显著变化。这些数据表明，chondocurine和粉防己碱对T细胞依赖性免疫反应有选择性抑制作用。
