两株创伤弧菌环境菌株经小鼠传代后毒力增强。
Enhancement of virulence of two environmental strains of Vibrio vulnificus after passage through mice.
作者信息
Kaysner C A, Wekell M M, Abeyta C
机构信息
Seafood Products Research Center, Food and Drug Administration, Bothell, Washington 98041-3012.
出版信息
Diagn Microbiol Infect Dis. 1990 Jul-Aug;13(4):285-8. doi: 10.1016/0732-8893(90)90018-q.
The virulence of two environmental strains of Vibrio vulnificus to iron-loaded adult mice was enhanced by passage through mice. Estimates of 50% lethal dose values (LD50) determined by end point titration were reduced 100- and 1000-fold for the two strains. Passage through mice also selected for the opaque colony type phase variation of V. vulnificus, reported by others to be more virulent to mice than a translucent colony type.
两株创伤弧菌环境菌株经小鼠传代后，对铁负荷成年小鼠的毒力增强。通过终点滴定法测定的50%致死剂量值（LD50）估计，这两株菌株分别降低了100倍和1000倍。经小鼠传代还筛选出了创伤弧菌的不透明菌落型相变，其他人报告称，该菌落型对小鼠的毒性比半透明菌落型更强。
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