新型喹诺酮抗菌剂司帕沙星（AT-4140、CI-978、PD 131501）的体外活性
In vitro activity of sparfloxacin (AT-4140, CI-978, PD 131501), a new quinolone antimicrobial agent.
作者信息
Eliopoulos G M, Klimm K, Grayson M L
机构信息
Department of Medicine, New England Deaconess Hospital, Boston, MA 02115.
出版信息
Diagn Microbiol Infect Dis. 1990 Jul-Aug;13(4):345-8. doi: 10.1016/0732-8893(90)90029-u.
PMID:2076597
Abstract
In vitro activity of sparfloxacin (AT-4140, CI-978, PD 131501) against clinical bacterial isolates was compared with those of ciprofloxacin and vancomycin or imipenem. Sparfloxacin was more active or equal to ciprofloxacin against most Gram-positive species and against Bacteroides fragilis, and it inhibited virtually all Enterobacteriaceae at 1.0 micrograms/ml or less.
摘要
将司帕沙星（AT - 4140、CI - 978、PD 131501）对临床分离菌的体外活性与环丙沙星和万古霉素或亚胺培南进行了比较。司帕沙星对大多数革兰氏阳性菌和脆弱拟杆菌的活性比环丙沙星更强或相当，并且在1.0微克/毫升或更低浓度时几乎能抑制所有肠杆菌科细菌。
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