Ban T A
J Clin Psychiatry. 1978 Jun;39(6):535-6, 541.
Hemodialysis resulted in remission of psychopathological symptoms in eight of ten chronic schizophrenics and successful hemodialysis was associated with a decrease of leucine endorphin levels in the blood. Three endorphins (endogenous peptides) have been isolated from the brain, and among them beta-endorphin was found to be the most potent in inducing behavioral changes in the rat. Nevertheless, neither a positive, nor an inverse relationship between the severity of schizophrenic psychopathology and CSF endorphin concentrations could be borne out by clinical experiments. Most recently, on the basis of an entirely different line of research, the possibility that schizophrenia is a prostaglandin deficiency disease has been raised.
血液透析使十名慢性精神分裂症患者中的八名精神病理症状得到缓解，而成功的血液透析与血液中亮氨酸内啡肽水平的降低有关。已从大脑中分离出三种内啡肽（内源性肽），其中β-内啡肽被发现是诱导大鼠行为变化最有效的。然而，临床实验未能证实精神分裂症精神病理学严重程度与脑脊液内啡肽浓度之间存在正相关或负相关。最近，基于一条完全不同的研究路线，有人提出精神分裂症可能是一种前列腺素缺乏症的可能性。
