Emrich H M, Höllt V, Kissling W, Fischler M, Laspe H, Heinemann H, von Zerssen D, Herz A
Pharmakopsychiatr Neuropsychopharmakol. 1979 May;12(3):269-76. doi: 10.1055/s-0028-1094620.
Measurements of beta-endorphin-like immunoreactivity have been performed in CSF and plasma of patients with schizophrenia and other neuropsychiatric disorders. The detection limit of the RIA was between 20--50 pg/ml (6--15 fmole/ml). In CSF the quantity of beta-endorphin-like immunoreactivity ranges up to 65 pg/ml. The data from schizophrenics and other neuropsychiatric patients show no obvious deviation from the results in a control group of medical patients with normal CSF findings. In plasma the immunoreactive beta-endorphin-like material ranges up to 250 pg/ml. There is only a small tendency to higher values in schizophrenic patients, if compared with different types of neuroses and affective and organic psychoses. In a second series of experiments also this tendency could not be reproduced. In 9 electroconvulsive treatments an increase of blood beta-endorphin-like immunoreactivity was observed 7 times. A possible endorphinergic mechanism in the mode of action of electroconvulsion is hypothesized.
已对精神分裂症患者及其他神经精神疾病患者的脑脊液和血浆中的β-内啡肽样免疫反应性进行了测量。放射免疫分析的检测限在20--50 pg/ml（6--15 fmole/ml）之间。脑脊液中β-内啡肽样免疫反应性的量高达65 pg/ml。精神分裂症患者和其他神经精神疾病患者的数据与脑脊液检查结果正常的内科患者对照组的结果相比，无明显偏差。血浆中免疫反应性β-内啡肽样物质高达250 pg/ml。与不同类型的神经症、情感性精神病和器质性精神病相比，精神分裂症患者中仅略有升高的趋势。在第二系列实验中，这种趋势也未能重现。在9次电休克治疗中，有7次观察到血液中β-内啡肽样免疫反应性增加。推测电休克作用方式中可能存在内啡肽能机制。
