Flynn A J, Dengerink H A, Wright J W
Department of Psychology, Washington State University, Vancouver 98663.
Hear Res. 1990 Dec;50(1-2):119-25. doi: 10.1016/0378-5955(90)90038-q.
Ovariectomized, castrated, and sham-castrated rats pretreated with oil or testosterone were intra-arterially infused with saline and three doses of angiotensin II while blood pressure and cochlear blood flow were measured. The results indicated a positive dose-response relationship for blood pressure and cochlear blood flow. Sham-castrated males had higher mean blood pressure responses than castrated males, followed by ovariectomized females. Cochlear blood flow responses were higher in the sham-castrated males than the ovariectomized females, followed by the castrated males. In comparison to the male groups, the ovariectomized females evidenced the lowest, middle, and highest cochlear blood flow responses to the three increasing doses of angiotensin II. Testosterone pretreatment facilitated angiotensin-induced cochlear blood flow elevations in all three angiotensin doses. These results suggest that endogenous and exogenous androgens may alter blood pressure and/or cochlear blood flow responses to angiotensin II via different mechanisms.
对用橄榄油或睾酮预处理过的去卵巢大鼠、去势大鼠和假去势大鼠进行动脉内输注生理盐水和三个剂量的血管紧张素II，同时测量血压和耳蜗血流量。结果表明血压和耳蜗血流量呈正剂量反应关系。假去势雄性大鼠的平均血压反应高于去势雄性大鼠，其次是去卵巢雌性大鼠。假去势雄性大鼠的耳蜗血流量反应高于去卵巢雌性大鼠，其次是去势雄性大鼠。与雄性组相比，去卵巢雌性大鼠对三种递增剂量的血管紧张素II的耳蜗血流量反应最低、中等和最高。睾酮预处理促进了所有三种血管紧张素剂量下血管紧张素诱导的耳蜗血流量升高。这些结果表明，内源性和外源性雄激素可能通过不同机制改变对血管紧张素II的血压和/或耳蜗血流量反应。
