脑室内注射血管紧张素II对大鼠和豚鼠血压及耳蜗血流的影响。

The effects of intracerebroventricularly administered angiotensin II on blood pressure and cochlear blood flow in rats and guinea pigs.

作者信息

Flynn A J, Quirk W S, Dengerink H A, Wright J W

机构信息

Department of Psychology, Washington State University, Pullman 99164-4830.

出版信息

Hear Res. 1989 Sep;41(2-3):249-54. doi: 10.1016/0378-5955(89)90016-6.

DOI:10.1016/0378-5955(89)90016-6

PMID:2808153

Abstract

Guinea pigs and Sprague-Dawley rats were intracerebroventricularly (icv) infused with various doses of angiotensin II (AII) in order to investigate central control of and species differences in cochlear blood flow (CBF) and blood pressure (BP). The results indicated a positive dose-response relationship between icv infusions of AII for BP and CBF in members of both species. This relationship was more predictable in the guinea pig than in the rat. In addition, responses to similar AII doses between species indicated that: a) BP elevations were significantly greater in the rat than in the guinea pig, b) CBF elevations were not significantly different between the rats and guinea pigs, and c) CBF was more highly correlated with BP in the guinea pig than in the rat. These results suggest that different relationships may exist between BP and CBF in rats and guinea pigs.

摘要

为了研究耳蜗血流量（CBF）和血压（BP）的中枢控制及种间差异，将不同剂量的血管紧张素II（AII）经脑室内（icv）注入豚鼠和斯普拉格-道利大鼠体内。结果表明，两种动物icv注入AII后，BP和CBF之间呈正剂量反应关系。这种关系在豚鼠中比在大鼠中更具可预测性。此外，种间对相似AII剂量的反应表明：a）大鼠的BP升高显著高于豚鼠；b）大鼠和豚鼠的CBF升高无显著差异；c）豚鼠的CBF与BP的相关性高于大鼠。这些结果表明，大鼠和豚鼠的BP与CBF之间可能存在不同的关系。