Munro J M, Ironside W, Smith G C
Department of Psychological Medicine, Monash University, Monash Medical Centre Prince Henry's Hospital, Melbourne, Victoria, Australia.
J In Vitro Fert Embryo Transf. 1990 Dec;7(6):332-6. doi: 10.1007/BF01130585.
A matched comparison was made of 158 parents of preschool twins conceived under three conditions; spontaneously, after infertility workup including drug treatment, and after in vitro fertilization (IVF). Indications of probable psychiatric caseness were obtained using the 60-item General Health Questionnaire. IVF parents' mean scores were similar to those of parents who spontaneously conceived, and both were significantly greater than those who conceived after an infertility workup. Mothers and fathers overall had similar scores, contrary to previous community findings of higher rates of psychiatric disorder among females. The prevalence of probable psychiatric caseness was less for IVF and spontaneously conceiving mothers, but greater for the respective fathers, than in an English community sample and greater than in an Australian community sample. The extent to which the self-reports of current psychiatric disturbance can be ascribed to any preexisting psychopathology is unknown. Indications of increased psychiatric disturbance found in this investigation warrant further prospective investigations, especially of the difficulties of rearing twins when couples are vulnerable in having this degree of psychiatric morbidity.
对158名在三种情况下受孕的学龄前双胞胎的父母进行了匹配比较；自然受孕、经过包括药物治疗在内的不孕症检查后受孕以及体外受精（IVF）后受孕。使用60项一般健康问卷获得可能患有精神疾病的指标。体外受精父母的平均得分与自然受孕父母的得分相似，且两者均显著高于经过不孕症检查后受孕的父母。总体而言，母亲和父亲的得分相似，这与之前社区研究中女性精神疾病发病率较高的结果相反。与英国社区样本相比，体外受精和自然受孕母亲中可能患有精神疾病的比例较低，但各自父亲的比例较高，且高于澳大利亚社区样本。目前精神障碍的自我报告在多大程度上可归因于任何先前存在的精神病理学尚不清楚。本调查中发现的精神障碍增加的迹象值得进一步进行前瞻性研究，特别是研究当夫妻有这种程度的精神疾病发病率时抚养双胞胎的困难。
