Moise J, Laor A, Armon Y, Gur I, Gale R
Department of Neonatology and NICU, Bikur Cholim Hospital, Jerusalem, Israel.
Hum Reprod. 1998 Jun;13(6):1702-5. doi: 10.1093/humrep/13.6.1702.
It has been suggested that the high rates of prematurity, low birth weight, perinatal morbidity and mortality in in-vitro fertilization (IVF) infants are due to the increased frequency of multiple gestations in this population. The aim of our study was to test this hypothesis by comparing the outcome of IVF twins with that of twins born after spontaneously conceived pregnancies. The perinatal outcome of 40 IVF twins was compared with that of 80 control twins, matched for maternal age, parity and ethnic origin. IVF twins had a higher rate of prematurity (P = 0.03), their mean birth weight was significantly lower (P < 0.01) and the frequency of very low birth weight infants was much higher (P < 0.003). There was no neonatal mortality in the control group, whereas four IVF twins died (P < 0.01). Neonatal morbidity was significantly greater in IVF twins (P < 0.05). Oxygen therapy and mechanical ventilation were administered more frequently to IVF twins (P < 0.007 and P < 0.05). We conclude that twins conceived by IVF are at a significantly higher risk for prematurity and associated neonatal morbidity and mortality than spontaneously conceived twins.
有人认为，体外受精（IVF）婴儿的早产、低出生体重、围产期发病率和死亡率较高，是由于该人群中多胎妊娠的频率增加所致。我们研究的目的是通过比较IVF双胞胎与自然受孕双胞胎的出生结局来验证这一假设。将40例IVF双胞胎的围产期结局与80例对照双胞胎进行比较，后者在母亲年龄、产次和种族方面相匹配。IVF双胞胎的早产率更高（P = 0.03），他们的平均出生体重显著更低（P < 0.01），极低出生体重婴儿的频率更高（P < 0.003）。对照组无新生儿死亡，而4例IVF双胞胎死亡（P < 0.01）。IVF双胞胎的新生儿发病率显著更高（P < 0.05）。IVF双胞胎接受氧气治疗和机械通气的频率更高（P < 0.007和P < 0.05）。我们得出结论，与自然受孕的双胞胎相比，IVF受孕的双胞胎早产以及相关新生儿发病率和死亡率的风险显著更高。
