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脱氢酶同工酶对的平行进化。

Parallel evolution of pairs of dehydrogenase isoenzymes.

作者信息

Senkbeil E, White H B

出版信息

J Mol Evol. 1978 May 12;11(1):57-66. doi: 10.1007/BF01768025.

DOI:10.1007/BF01768025
PMID:207878
Abstract

Lactate dehydrogenase and glycerol 3-phosphate dehydrogenase are metabolically coupled by the anaerobic dismutation of glyceraldehyde 3-phosphate and by the NAD redox state. This causes the concentrations of lactate and glycerol 3-phosphate to accumulate proportionally during anaerobic muscle contraction; these concentrations are high relative to those in aerobic tissues such as liver. We show that the isoenzymes of lactate dehydrogenase and glycerol 3-phosphate dehydrogenase from chicken breast muscle have Km values for lactate and glycerol 3-phosphate, respectively, that are 10-fold higher than the Km values measured for the lactate dehydrogenase and glycerol 3-phosphate dehydrogenase isoenzymes from chicken liver. The association of proportionally higher Km values with the potential for proportionally higher accumulation of substrates suggests that the isoenzymes of lactate dehydrogenase and glycerol 3-phosphate dehydrogenase from chicken muscle have evolved in parallel as a coupled metabolic unit distinct from the coupled isoenzymes in liver. The parallelism observed for the reduced substrates extends to the oxidized substrates, and to the coenzymes, NAD+ and NADH.

摘要

乳酸脱氢酶和3-磷酸甘油脱氢酶通过3-磷酸甘油醛的厌氧歧化作用以及NAD氧化还原状态在代谢上相互偶联。这导致在无氧肌肉收缩过程中,乳酸和3-磷酸甘油的浓度按比例积累;相对于肝脏等有氧组织中的浓度,这些浓度较高。我们发现,鸡胸肌中的乳酸脱氢酶和3-磷酸甘油脱氢酶同工酶对乳酸和3-磷酸甘油的Km值分别比从鸡肝中测得的乳酸脱氢酶和3-磷酸甘油脱氢酶同工酶的Km值高10倍。比例较高的Km值与底物比例较高的积累潜力相关联,这表明鸡肌肉中的乳酸脱氢酶和3-磷酸甘油脱氢酶同工酶作为一个与肝脏中偶联的同工酶不同的偶联代谢单元平行进化。观察到的还原底物的平行性延伸到氧化底物以及辅酶NAD⁺和NADH。

相似文献

1
Parallel evolution of pairs of dehydrogenase isoenzymes.脱氢酶同工酶对的平行进化。
J Mol Evol. 1978 May 12;11(1):57-66. doi: 10.1007/BF01768025.
2
Ability of cytosolic malate dehydrogenase and lactate dehydrogenase to increase the ratio of NADPH to NADH oxidation by cytosolic glycerol-3-phosphate dehydrogenase.胞质苹果酸脱氢酶和乳酸脱氢酶通过胞质甘油-3-磷酸脱氢酶提高NADPH与NADH氧化比率的能力。
Arch Biochem Biophys. 1999 Apr 15;364(2):185-94. doi: 10.1006/abbi.1999.1117.
3
[Functional interrelations between isozymes of dehydrogenases in the intact and denervated rabbit muscles].[完整及去神经支配兔肌肉中脱氢酶同工酶之间的功能相互关系]
Biokhimiia. 1977 Feb;42(2):311-9.
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Lactate dehydrogenase A-subunit and B-subunit deficiencies: comparison of the physiological roles of LDH isozymes.乳酸脱氢酶A亚基和B亚基缺乏症:乳酸脱氢酶同工酶生理作用的比较
Isozymes Curr Top Biol Med Res. 1983;7:131-50.
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Reexamination of the kinetics of the transfer of NADH between its complexes with glycerol-3-phosphate dehydrogenase and with lactate dehydrogenase.重新审视烟酰胺腺嘌呤二核苷酸(NADH)在其与甘油-3-磷酸脱氢酶复合物以及与乳酸脱氢酶复合物之间转移的动力学。
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Purification and properties of the major isozymic form of cytoplasmic glycerol-3-phosphate dehydrogenase from rabbit liver.兔肝细胞质3-磷酸甘油脱氢酶主要同工酶形式的纯化及性质
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Role of glycerol 3-phosphate dehydrogenase in glyceride metabolism. Effect of diet on enzyme activities in chicken liver.甘油-3-磷酸脱氢酶在甘油酯代谢中的作用。日粮对鸡肝脏中酶活性的影响。
Biochem J. 1975 Jan;146(1):223-9. doi: 10.1042/bj1460223.
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Direct transfer of NADH between alpha-glycerol phosphate dehydrogenase and lactate dehydrogenase: fact or misinterpretation?α-甘油磷酸脱氢酶与乳酸脱氢酶之间NADH的直接转移:事实还是误解?
Proc Natl Acad Sci U S A. 1989 Sep;86(17):6464-8. doi: 10.1073/pnas.86.17.6464.
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The importance of the glycerol 3-phosphate shuttle during aerobic growth of Saccharomyces cerevisiae.甘油-3-磷酸穿梭在酿酒酵母有氧生长过程中的重要性。
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[Correlation between the histochemical demonstration of glycerol 1-phosphate oxidase and LDH isoenzyme pattern in skeletal muscle].[骨骼肌中磷酸甘油氧化酶的组织化学显示与乳酸脱氢酶同工酶模式之间的相关性]
Acta Histochem Suppl. 1984;30:257-63.

引用本文的文献

1
Multilocus enzymes, gene regulation, and genetic sufficiency.多位点酶、基因调控与基因充足性。
J Mol Evol. 1978 Oct 27;12(1):57-89. doi: 10.1007/BF01732545.

本文引用的文献

1
Separate physiological roles for two isozymes of pyridine nucleotide-linked glycerol-3-phosphate dehydrogenase in chicken.在鸡中,两种吡啶核苷酸连接的甘油-3-磷酸脱氢酶同工酶具有不同的生理功能。
J Mol Evol. 1972 Jun;1(2):158-72. doi: 10.1007/BF01659162.
2
Enzyme kinetics.酶动力学
Annu Rev Biochem. 1967;36:77-112. doi: 10.1146/annurev.bi.36.070167.000453.
3
Biological oxidations.生物氧化
Annu Rev Biochem. 1960;29:669-708. doi: 10.1146/annurev.bi.29.070160.003321.
4
FACTORS INFLUENCING THE CONCENTRATION OF ENZYMES IN VARIOUS MUSCLES.影响不同肌肉中酶浓度的因素。
J Biol Chem. 1965 Jul;240:3215-21.
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DIPHOSPHOPYRIDINE NUCLEOTIDE-LINKED CYTOPLASMIC METABOLITES IN RAT LEG MUSCLE IN SITU DURING CONTRACTION AND RECOVERY.收缩和恢复过程中原位大鼠腿部肌肉中与二磷酸吡啶核苷酸相关的细胞质代谢物
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6
DISC ELECTROPHORESIS. II. METHOD AND APPLICATION TO HUMAN SERUM PROTEINS.圆盘电泳。II. 方法及其在人血清蛋白中的应用。
Ann N Y Acad Sci. 1964 Dec 28;121:404-27. doi: 10.1111/j.1749-6632.1964.tb14213.x.
7
THE COMPARATIVE ENZYMOLOGY OF LACTIC DEHYDROGENASES. I. PROPERTIES OF THE CRYSTALLINE BEEF AND CHICKEN ENZYMES.乳酸脱氢酶的比较酶学。I. 结晶牛肉和鸡肉酶的性质。
J Biol Chem. 1964 Jun;239:1753-61.
8
THE COMPARATIVE ENZYMOLOGY OF LACTIC DEHYDROGENASES. II. PROPERTIES OF THE CRYSTALLINE HM3 HYBRID FROM CHICKEN MUSCLE AND OF H2M2 HYBRID AND H4 ENZYME FROM CHICKEN LIVER.乳酸脱氢酶的比较酶学。II. 鸡肌肉中结晶HM3杂合体以及鸡肝脏中H2M2杂合体和H4酶的特性
Biochemistry. 1964 Apr;3:522-30. doi: 10.1021/bi00892a010.
9
THE RELATIONSHIPS BETWEEN SUBSTRATES AND ENZYMES OF GLYCOLYSIS IN BRAIN.大脑中糖酵解的底物与酶之间的关系
J Biol Chem. 1964 Jan;239:31-42.
10
LACTIC DEHYDROGENASES: FUNCTIONS OF THE TWO TYPES RATES OF SYNTHESIS OF THE TWO MAJOR FORMS CAN BE CORRELATED WITH METABOLIC DIFFERENTIATION.乳酸脱氢酶:两种类型的功能 两种主要形式的合成速率与代谢分化相关。
Science. 1964 Feb 28;143(3609):929-33. doi: 10.1126/science.143.3609.929.