Hashimoto M
Department of Physiology, Shimane Medical University, Japan.
Eur J Appl Physiol Occup Physiol. 1990;61(5-6):440-5. doi: 10.1007/BF00236065.
Effects of treadmill exercise (1 h.day-1 for 12 weeks) on the mechanical properties of isolated aortae and plasma concentrations of low and high density lipoprotein cholesterols ([LDL-C]pl and [HDL-C]pl, respectively) were investigated in young (16 weeks) and old (98 weeks) rats. With aging, [LDL-C]pl increased and acetylcholine (ACh) elicited greater endothelium-dependent relaxations of the aorta in old rats than in young rats. Also, in all groups of rats tested (young, old, exercised and nonexercised), the increase in the [LDL-C]pl correlated with an increase in the sensitivity of relaxation of the aorta to ACh. On the other hand, a greater [HDL-C]pl was associated with a smaller relaxation response to ACh in young rats only when exercised and nonexercised groups were combined. The increase in [HDL-C]pl with aging, however, did not correlate with the extent of ACh-induced relaxation. Exercise in old rats reduced [LDL-C]pl and the extent of ACh-induced relaxation of the aorta. Therefore, [LDL-C]pl appeared to be closely related to the extent of endothelium-dependent relaxation in response to ACh in the aorta. The [LDL-C]pl also correlated with the gain in mass of the rat. Exercise in old rats reduced the body mass and was accompanied by a decrease in [LDL-C]pl.
研究了跑步机运动（每天1小时，持续12周）对年轻（16周）和老年（98周）大鼠离体主动脉力学性能以及血浆中低密度脂蛋白胆固醇和高密度脂蛋白胆固醇浓度（分别为[LDL-C]pl和[HDL-C]pl）的影响。随着年龄增长，老年大鼠的[LDL-C]pl升高，乙酰胆碱（ACh）引起的主动脉内皮依赖性舒张比年轻大鼠更大。此外，在所有测试的大鼠组（年轻、老年、运动和未运动）中，[LDL-C]pl的升高与主动脉对ACh舒张敏感性的增加相关。另一方面，仅在将运动组和未运动组合并时，年轻大鼠中较高的[HDL-C]pl与对ACh的较小舒张反应相关。然而，随着年龄增长[HDL-C]pl的升高与ACh诱导的舒张程度无关。老年大鼠运动可降低[LDL-C]pl和主动脉对ACh诱导的舒张程度。因此，[LDL-C]pl似乎与主动脉对ACh的内皮依赖性舒张程度密切相关。[LDL-C]pl也与大鼠体重增加相关。老年大鼠运动可减轻体重，并伴有[LDL-C]pl的降低。
