Hashimoto M, Masumura S
Department of Physiology, Shimane Medical University, Izumo, Japan.
Eur J Appl Physiol Occup Physiol. 1988;57(5):639-43. doi: 10.1007/BF00418476.
Young exercised rats with a diminished weight gain had a decrease in high density lipoprotein (HDL) cholesterol and phospholipid levels in the plasma and augmented free cholesterol and phosphatide in the aorta. When the weight gain in the trained rats paralleled the gain in non-exercised animals, the values of these lipids were not altered. The levels of aortic free cholesterol in the non-exercised and exercised groups were inversely associated with concentrations of HDL-cholesterol, but were not related to the activities of lecithin cholesterol acyltransferase. In addition, the total cholesterol and phospholipid contents in the aorta negatively correlated with HDL-cholesterol concentrations. We propose that in young exercised rats with a diminished weight gain, the removal of aortic lipids is hampered due to a reduction in HDL-cholesterol.
体重增加减少的年轻运动大鼠血浆中高密度脂蛋白（HDL）胆固醇和磷脂水平降低，主动脉中游离胆固醇和磷脂增加。当训练大鼠的体重增加与未运动动物的体重增加相平行时，这些脂质的值没有改变。未运动组和运动组主动脉游离胆固醇水平与HDL胆固醇浓度呈负相关，但与卵磷脂胆固醇酰基转移酶活性无关。此外，主动脉中总胆固醇和磷脂含量与HDL胆固醇浓度呈负相关。我们提出，在体重增加减少的年轻运动大鼠中，由于HDL胆固醇减少，主动脉脂质的清除受到阻碍。
