阿司匹林特异反应患者哮喘发作时血浆中的前列腺素水平。
Prostaglandin levels in blood plasma during asthmatic attacks in patients with aspirin idiosyncrasy.
作者信息
Delaney J C, Smith J B, Silver M J
出版信息
Postgrad Med J. 1975 Jan;51(591):15-7. doi: 10.1136/pgmj.51.591.15.
Abstract
It has been suggested that prostaglandin release is an important factor in the pathogenesis of bronchial asthma. Aspirin inhibits prostaglandin synthesis, yet there are a group of patients, with aspirin idiosyncrasy, who develop asthma after ingestion of aspirin. We measured prostaglandin levels in seven individuals with this syndrome. Only trace amounts of PGE and PGF were found in plasma during asthmatic attacks provoked by aspirin.
摘要
有人提出，前列腺素释放是支气管哮喘发病机制中的一个重要因素。阿司匹林可抑制前列腺素合成，但有一组对阿司匹林过敏的患者，在摄入阿司匹林后会引发哮喘。我们测量了7名患有该综合征患者的前列腺素水平。在阿司匹林诱发的哮喘发作期间，血浆中仅发现微量的前列腺素E和前列腺素F。
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