Cialfi A, Pernpruner S, Ravagnan S, Sala R, Castelfranco M, Salati M, Santoli C
Divisione di Cardiologia, Ospedale L. Sacco, Milano.
G Ital Cardiol. 1990 Sep;20(9):834-41.
The aim of conservative management of mitral regurgitation caused by floppy mitral valve is to restore a valvular function which closely resembles that of normal physiology. Fifty-eight patients affected by floppy mitral valve underwent surgical procedures for severe mitral regurgitation due to chordal elongation and/or rupture. Of these, 28 presented posterior mitral prolapse corrected by quadrangular excision of the prolapsed part and posterior anuloplasty achieved by apposition of a polytetrafluoroethylene conduit. The remaining 30 patients presented anterior or bilateral prolapse corrected by transposition of chordae from the posterior leaflet to the anterior cusp together together with anuloplasty. A complete echo-Doppler study was performed preoperatively, 10 days after the operation and every 6 months thereafter. Mean follow-up was 16.1 +/- 6.3 months. Preoperatively, 44 patients presented severe mitral regurgitation and 14 had moderate regurgitation (quantified by means of pulsed Doppler). All patients showed severe enlargement of the left cavities (LVDD 67.1 +/- 8.6 mm, left atrium 53.4 +/- 10.9 mm) with normal mitral area (6.08 +/- 2.14 sqcm, Doppler measurement). Following surgery we found a significant reduction in: 1) the degree of mitral regurgitation (29 patients had no regurgitation; 20 had mild protosystolic mitral regurgitation (29 patients had no regurgitation; 20 had mild protosystolic mitral regurgition, confirmed by color-M-mode; moderate or severe regurgitation was found in 6 cases); 2) the left ventricle and left atrium dimensions (LVDD 53.4 +/- 5.2 mm, p less than 0.01; left atrium 43.8 +/- 11.1 mm, p less than 0.01). Color flow imaging provided information about the recovery of a normal valvular function.(ABSTRACT TRUNCATED AT 250 WORDS)
二尖瓣脱垂所致二尖瓣反流的保守治疗目的是恢复与正常生理功能极为相似的瓣膜功能。58例二尖瓣脱垂患者因腱索延长和/或断裂导致严重二尖瓣反流而接受了外科手术。其中,28例表现为二尖瓣后叶脱垂,通过脱垂部分的四边形切除及使用聚四氟乙烯导管进行二尖瓣后瓣环成形术得以矫正。其余30例患者表现为前叶或双侧脱垂,通过将后叶腱索转移至前叶瓣尖并同时进行瓣环成形术进行矫正。术前、术后10天及此后每6个月进行一次完整的超声多普勒检查。平均随访时间为16.1±6.3个月。术前,44例患者存在严重二尖瓣反流,14例为中度反流(通过脉冲多普勒定量)。所有患者均显示左心腔严重扩大(左室舒张末期内径67.1±8.6mm,左心房53.4±10.9mm),二尖瓣面积正常(6.08±2.14平方厘米,多普勒测量)。术后我们发现:1)二尖瓣反流程度显著降低(29例无反流;20例有轻度收缩期二尖瓣反流,经彩色M型证实;6例发现中度或重度反流);2)左心室和左心房尺寸减小(左室舒张末期内径53.4±5.2mm,p<0.01;左心房43.8±11.1mm,p<0.01)。彩色血流成像提供了有关瓣膜功能恢复正常的信息。(摘要截选至250字)