Tzias V, Dontas A S, Petrikkos G, Papapetropoulou M, Dracopoulos J, Giamarellou H
Centre for Studies of Age-Related Changes in Man, Athens, Greece.
J Antimicrob Chemother. 1990 Nov;26(5):705-11. doi: 10.1093/jac/26.5.705.
A three day oral antibiotic course was given to 71 elderly bacteriuric subjects with no or only moderate mobility problems. Seven of 17 men (41%) and 34 of 54 women (63%) had strongly positive antibody coated bacteria (ACB) in the urine. Following sensitivity tests and randomization one of the following agents was given: cefadroxil 1 g tid (13 subjects): co-trimoxazole 160/800 mg bd (23 subjects); or norfloxacin 400 mg bd (35 subjects). One week after therapy urines were negative in 13 men (76.5%) and 37 women (68.5%). Patients who were fully mobile and/or were ACB(-) responded better than those with moderate mobility problems or who were ACB(+). At six months, urines were negative in six (40%) of 15 men and 15 (33.3%) of 45 women. Two men and six women of these 21 subjects had a positive urine at one month. Of the three agents tested cefadroxil was less effective in women. The study indicates that a three day course will clear bacteriuria in about 70% of patients at one week, but only about 25% will remain free of infection at six months; these are usually patients with adequate mobility and normal renal function.
对71名无或仅有中度行动不便问题的老年菌尿症患者进行了为期三天的口服抗生素治疗。17名男性中有7名（41%），54名女性中有34名（63%）尿液中抗体包裹细菌（ACB）呈强阳性。经过药敏试验和随机分组后，给予以下药物之一：头孢羟氨苄1克，每日三次（13名受试者）；复方新诺明160/800毫克，每日两次（23名受试者）；或诺氟沙星400毫克，每日两次（35名受试者）。治疗一周后，13名男性（76.5%）和37名女性（68.5%）的尿液呈阴性。行动自如和/或ACB（-）的患者比有中度行动不便问题或ACB（+）的患者反应更好。六个月时，15名男性中有6名（40%）、45名女性中有15名（33.3%）的尿液呈阴性。这21名受试者中有2名男性和6名女性在一个月时尿液呈阳性。在测试的三种药物中，头孢羟氨苄对女性的效果较差。该研究表明，为期三天的疗程在一周时可使约70%的患者菌尿症清除，但六个月时只有约25%的患者无感染；这些患者通常行动能力良好且肾功能正常。
