Bryson D G, Ball H J, McAliskey M, McConnell W, McCullough S J
Veterinary Research Laboratories, Stormont, Belfast, Northern Ireland.
J Comp Pathol. 1990 Nov;103(4):433-45. doi: 10.1016/s0021-9975(08)80031-x.
Pathological, immunocytochemical and microbiological findings in 32 cases of calf pneumonia associated with Haemophilus somnus infection are described. The majority of cases were "found dead" or died after a sudden onset pneumonia of less than 24 h duration. Lesions of exudative bronchopneumonia were present and the cases could be divided into two main groups on the basis of histopathological and immunocytochemical features. In group A, cases were dominated by necrotizing bronchiolitis, degeneration and necrosis of airway and alveolar exudates, severe alveolitis with accumulations of degenerate basophilic cells, interstitial inflammatory changes and the widespread distribution of H. somnus antigen in airways and alveoli. In Group B, necrotizing and degenerative changes were much less extensive and less severe and the overall appearance was of suppurative bronchopneumonia with H. somnus antigen much less widespread within the lungs. Alveolar oedema, hyaline membrane formation and alveolar epithelial hyperplasia were present in caudodorsal lung areas of several calves. No major differences were seen between the histopathology of lungs where H. somnus was the sole isolate and that of lungs where H. somnus was isolated along with other bacterial pathogens.
本文描述了32例与睡眠嗜血杆菌感染相关的犊牛肺炎的病理学、免疫细胞化学和微生物学研究结果。大多数病例为“发现死亡”或在突发持续时间不到24小时的肺炎后死亡。存在渗出性支气管肺炎病变，根据组织病理学和免疫细胞化学特征，这些病例可分为两个主要组。在A组中，病例以坏死性细支气管炎、气道和肺泡渗出物的变性和坏死、严重的肺泡炎伴变性嗜碱性细胞积聚、间质性炎症变化以及睡眠嗜血杆菌抗原在气道和肺泡中的广泛分布为主。在B组中，坏死和变性变化的范围和严重程度要小得多，总体表现为化脓性支气管肺炎，睡眠嗜血杆菌抗原在肺内的分布要少得多。几只犊牛的肺尾背侧区域出现肺泡水肿、透明膜形成和肺泡上皮增生。在仅分离出睡眠嗜血杆菌的肺组织病理学与同时分离出睡眠嗜血杆菌和其他细菌病原体的肺组织病理学之间未发现重大差异。
