Allan E M, Gibbs H A, Wiseman A, Selman I E
Vet Rec. 1985 Oct 26;117(17):438-42. doi: 10.1136/vr.117.17.438.
A strain of Pasteurella haemolytica biotype A serotype 1, which had been isolated from a pathologically-confirmed outbreak of bovine pneumonic pasteurellosis, was used successfully to reproduce the disease in conventional calves. The development of the various pathological features was studied at regular intervals following infection. The acute inflammatory reaction which had developed by day 2 after initial infection was characterised by flooding of the alveoli by oedema and neutrophils together with a mild degree of bronchiolar epithelial necrosis. This progressed to an acute exudative fibrinous pneumonia with extensive involvement of the interlobular septa and often with pleurisy. Subsequently, these pulmonary lesions became walled off by fibrous tissue which became infiltrated by plasma cells and lymphocytes. At this stage organisms could be demonstrated only within these nodules in the lung tissue.
从经病理确诊的牛肺巴氏杆菌病暴发中分离出的一株溶血巴氏杆菌生物型A血清型1，成功用于在常规犊牛中再现该病。在感染后定期研究各种病理特征的发展情况。初次感染后第2天出现的急性炎症反应的特征是肺泡被水肿液和中性粒细胞充斥，伴有轻度细支气管上皮坏死。这进展为急性渗出性纤维素性肺炎，小叶间隔广泛受累，常伴有胸膜炎。随后，这些肺部病变被纤维组织包裹，纤维组织中有浆细胞和淋巴细胞浸润。在这个阶段，仅在肺组织中的这些结节内可检测到病原体。
