UMR145, Institut de Recherche pour le Developpement (IRD) and University of Montpellier 1, Montpellier, France.
J Gen Virol. 2010 Dec;91(Pt 12):2959-64. doi: 10.1099/vir.0.025767-0. Epub 2010 Aug 25.
Simian immunodeficiency viruses (SIVs) are lentiviruses that infect an extensive number of wild African primate species. Here we describe for the first time SIV infection in a captive agile mangabey (Cercocebus agilis) from Cameroon. Phylogenetic analysis of the full-length genome sequence of SIVagi-00CM312 showed that this novel virus fell into the SIVrcm lineage and was most closely related to a newly characterized SIVrcm strain (SIVrcm-02CM8081) from a wild-caught red-capped mangabey (Cercocebus torquatus) from Cameroon. In contrast to red-capped mangabeys, no 24 bp deletion in CCR5 has been observed in the agile mangabey. Further studies on wild agile mangabeys are needed to determine whether agile and red-capped mangabeys are naturally infected with the same SIV lineage, or whether this agile mangabey became infected with an SIVrcm strain in captivity. However, our study shows that agile mangabeys are susceptible to SIV infection.
猿猴免疫缺陷病毒（SIVs）是一种感染大量野生非洲灵长类动物的慢病毒。在这里，我们首次描述了来自喀麦隆的圈养敏捷长尾猴（Cercocebus agilis）感染 SIV 的情况。SIVagi-00CM312 的全长基因组序列的系统进化分析表明，这种新型病毒属于 SIVrcm 谱系，与最近从喀麦隆野生捕获的红帽长尾猴（Cercocebus torquatus）中分离到的一种新 SIVrcm 毒株（SIVrcm-02CM8081）最为密切相关。与红帽长尾猴不同，在敏捷长尾猴中没有观察到 CCR5 中的 24 bp 缺失。需要对野生敏捷长尾猴进行进一步研究，以确定敏捷长尾猴和红帽长尾猴是否自然感染相同的 SIV 谱系，或者这只敏捷长尾猴是否在圈养中感染了 SIVrcm 株。然而，我们的研究表明，敏捷长尾猴易感染 SIV。
