Aghokeng Avelin F, Bailes Elizabeth, Loul Severin, Courgnaud Valerie, Mpoudi-Ngolle Eitel, Sharp Paul M, Delaporte Eric, Peeters Martine
Laboratoire Retrovirus, UMR 145, IRD and the Department of International Health, University of Montpellier I, Montpellier, France.
Virology. 2007 Apr 10;360(2):407-18. doi: 10.1016/j.virol.2006.10.048. Epub 2006 Dec 6.
Mustached monkeys (Cercopithecus cephus), which form a significant component of primate bushmeat in west central Africa, are infected with simian immunodeficiency virus (SIVmus). We identified and genetically characterized five new SIVmus strains infecting wild living mustached monkeys from Cameroon. Phylogenetic analysis of partial pol sequences revealed that SIVmus strains form two distinct groups within the clade comprised of lentiviruses isolated from Cercopithecus nictitans (SIVgsn), Cercopithecus mona (SIVmon) and C. cephus (SIVmus). Characterisation of three full-length SIVmus genomes confirmed the presence of two distinct lineages infecting mustached monkeys. These two variants of SIVmus, here designated SIVmus-1 and SIVmus-2, were isolated from animals sharing habitats within the same geographic region. Phylogenetic analyses showed that the diversification of SIVmus, SIVgsn and SIVmon involved inter-lineage recombination, and suggested that one of the SIVmus lineages likely resulted from cross-species transmission and recombination involving SIVmus and an as yet uncharacterized SIV. These results indicate that cross-species transmission and recombination play a major role in the evolution of primate lentiviruses among sympatric primate species.
髭猴（Cercopithecus cephus）是中非西部灵长类丛林肉的重要组成部分，感染了猴免疫缺陷病毒（SIVmus）。我们鉴定并对五种感染喀麦隆野生髭猴的新SIVmus毒株进行了基因特征分析。对部分pol序列的系统发育分析表明，SIVmus毒株在由从黑额白眉猴（SIVgsn）、戴安娜须猴（SIVmon）和髭猴（SIVmus）分离出的慢病毒组成的进化枝内形成两个不同的组。对三个全长SIVmus基因组的特征分析证实存在两种感染髭猴的不同谱系。这两种SIVmus变体，在这里命名为SIVmus-1和SIVmus-2，是从同一地理区域内共享栖息地的动物中分离出来的。系统发育分析表明，SIVmus、SIVgsn和SIVmon的多样化涉及谱系间重组，并表明其中一个SIVmus谱系可能是由涉及SIVmus和一种尚未鉴定的SIV的跨物种传播和重组导致的。这些结果表明，跨物种传播和重组在同域灵长类物种中灵长类慢病毒的进化中起主要作用。
