佛罗里达蚁和猎镰猛蚁的基因组比较。
Genomic comparison of the ants Camponotus floridanus and Harpegnathos saltator.
机构信息
Department of Biochemistry, New York University School of Medicine, 522 First Avenue, New York, NY 10016, USA.
出版信息
Science. 2010 Aug 27;329(5995):1068-71. doi: 10.1126/science.1192428.
Abstract
The organized societies of ants include short-lived worker castes displaying specialized behavior and morphology and long-lived queens dedicated to reproduction. We sequenced and compared the genomes of two socially divergent ant species: Camponotus floridanus and Harpegnathos saltator. Both genomes contained high amounts of CpG, despite the presence of DNA methylation, which in non-Hymenoptera correlates with CpG depletion. Comparison of gene expression in different castes identified up-regulation of telomerase and sirtuin deacetylases in longer-lived H. saltator reproductives, caste-specific expression of microRNAs and SMYD histone methyltransferases, and differential regulation of genes implicated in neuronal function and chemical communication. Our findings provide clues on the molecular differences between castes in these two ants and establish a new experimental model to study epigenetics in aging and behavior.
摘要
蚁群中有组织的社会包括寿命较短的工蚁，它们表现出专门的行为和形态，以及寿命较长的蚁后，致力于繁殖。我们对两种社会分化的蚂蚁物种：佛罗里达弓背蚁和猎镰猛蚁的基因组进行了测序和比较。尽管存在 DNA 甲基化，但这两种基因组都含有大量的 CpG，而在非膜翅目动物中，CpG 会减少。对不同蚁群中基因表达的比较表明，寿命较长的猎镰猛蚁繁殖蚁中，端粒酶和 Sirtuin 去乙酰化酶的表达上调，特定蚁群表达 microRNA 和 SMYD 组蛋白甲基转移酶，以及与神经元功能和化学通讯相关的基因的表达受到差异调控。我们的发现为这两种蚂蚁中不同蚁群之间的分子差异提供了线索，并建立了一个新的实验模型来研究衰老和行为中的表观遗传学。
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