Department of Neonatology, Charité University Medicine, Berlin, Germany.
Neonatology. 2011;99(3):163-9. doi: 10.1159/000308448. Epub 2010 Aug 27.
By 1769, it was known to Morgagni that the ductus arteriosus may persist until adulthood. In 1835, Jörg linked delayed postnatal closure with disturbed respiration, a discovery that was afterwards forgotten for a century. When blood gas analysis became available, the association between persisting patency and diminished oxygenation resurfaced. When it became known that prostaglandins played a role in maintaining ductal patency, the development of pharmacologic intervention with cyclooxygenase inhibitors immediately followed. This rapid progress was due to the interaction between basic science, pediatric cardiology, and neonatology disciplines at the Cardiovascular Research Institute in San Francisco, coordinated by Julius Comroe, as well as President Kennedy's foundation of the National Institute of Child Health and Development. This series of events exemplifies how clinical research became an integrated managed multidisciplinary endeavor in the 20th century.
到 1769 年，莫尔加尼已经知道动脉导管可能会持续到成年期。1835 年，乔格将出生后延迟闭合与呼吸障碍联系起来，这一发现后来被遗忘了一个世纪。当血液气体分析可用时，持续开放与氧合减少之间的关联再次出现。当人们知道前列腺素在维持导管通畅方面发挥作用时，用环氧化酶抑制剂进行药物干预的发展立即随之而来。这种快速进展是由于旧金山心血管研究所的基础科学、儿科心脏病学和新生儿学之间的相互作用，由朱利叶斯·科莫罗（Julius Comroe）协调，以及肯尼迪总统成立国家儿童健康与发展研究所。这一系列事件说明了临床研究如何在 20 世纪成为一个集成的、管理的多学科努力。
