O'Connor-Giles Kate M, Ganetzky Barry
Laboratory of Genetics, University of Wisconsin - Madison, Madison, Wisconsin 53706, USA.
Fly (Austin). 2008 Sep-Oct;2(5):259-61. doi: 10.4161/fly.7133. Epub 2008 Sep 7.
Neural function requires effective communication between neurons and their targets at synapses. Thus, proper formation, growth and plasticity of synapses are critical to behavior. A retrograde (muscle to neuron) BMP signal is required to promote synaptic growth, homeostasis and stability at Drosophila neuromuscular junctions (NMJs).(1-4) We recently demonstrated that this signal constitutes an instructive signal that sculpts synaptic growth in a graded manner and uncovered a presynaptic endocytic mechanism that modulates BMP signaling levels. In the absence of this regulation, excessive BMP signaling results in overgrown NMJs with a proliferation of ectopic boutons.(5).
神经功能需要神经元与其突触靶标之间进行有效的通讯。因此，突触的正确形成、生长和可塑性对于行为至关重要。在果蝇神经肌肉接头（NMJ）处，逆行性（从肌肉到神经元）骨形态发生蛋白（BMP）信号是促进突触生长、稳态和稳定性所必需的。（1 - 4）我们最近证明，该信号构成一种指导性信号，以分级方式塑造突触生长，并发现了一种调节BMP信号水平的突触前内吞机制。在缺乏这种调节的情况下，过量的BMP信号会导致NMJ过度生长，伴有异位轴突末梢的增殖。（5）
