基于鸟苷的基序形成纤维状和层状自组装体的分层结构。

Hierarchical formation of fibrillar and lamellar self-assemblies from guanosine-based motifs.

作者信息

Neviani Paolo, Sarazin Dominique, Schmutz Marc, Blanck Christian, Giuseppone Nicolas, Spada Gian Piero

机构信息

Dipartimento di Chimica Organica "A. Mangini", Alma Mater Studiorum-Università di Bologna, Via San Giacomo 11, 40126 Bologna, Italy.

出版信息

J Nucleic Acids. 2010 Jul 13;2010:938536. doi: 10.4061/2010/938536.

DOI:10.4061/2010/938536

PMID:20798860

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2925466/

Abstract

Here we investigate the supramolecular polymerizations of two lipophilic guanosine derivatives in chloroform by light scattering technique and TEM experiments. The obtained data reveal the presence of several levels of organization due to the hierarchical self-assembly of the guanosine units in ribbons that in turn aggregate in fibrillar or lamellar soft structures. The elucidation of these structures furnishes an explanation to the physical behaviour of guanosine units which display organogelator properties.

摘要

在此，我们通过光散射技术和透射电子显微镜实验研究了两种亲脂性鸟苷衍生物在氯仿中的超分子聚合。所获得的数据揭示了由于鸟苷单元在条带中分层自组装而导致的多个组织层次的存在，这些条带又聚集形成纤维状或层状软结构。对这些结构的阐明为具有有机凝胶剂特性的鸟苷单元的物理行为提供了解释。