Department of Radiology, National Center Hospital of Neurology and Psychiatry, Kodaira, Tokyo, Japan.
Jpn J Radiol. 2010 Aug;28(7):494-501. doi: 10.1007/s11604-010-0460-y. Epub 2010 Aug 27.
Magnetic resonance diffusion tensor imaging is a noninvasive technique that can identify white matter tracts by evaluating bulk diffusion of water in three dimensions and can thus describe the microarchitectural characteristics of local brain tissue. Several recent reports have shown that mapping of diffusion parameters is potentially useful for speculating about the pathology of Alzheimer disease (AD). These reports have employed image-analysis approaches, including region-of-interest measurement, voxel-based analysis, tract-based spatial statistics, and tract-specific analysis (TSA). The present review focuses on TSA to investigate AD. An overview of the changes in diffusion properties of AD measured using TSA is presented and discussed.
磁共振扩散张量成像是一种非侵入性技术，可通过评估水在三维空间中的整体扩散来识别白质束，从而描述局部脑组织的微观结构特征。最近有几项报告表明，扩散参数的映射对于推测阿尔茨海默病 (AD) 的病理学可能是有用的。这些报告采用了图像分析方法，包括感兴趣区测量、体素基础分析、基于束的空间统计学和束特异性分析 (TSA)。本综述重点介绍 TSA 以研究 AD。介绍并讨论了使用 TSA 测量的 AD 扩散特性变化的概述。
