Department of Pediatrics, Lady Hardinge Medical College and Kalawati Saran Children's Hospital, New Delhi 110001, India.
Indian J Pediatr. 2010 Sep;77(9):981-5. doi: 10.1007/s12098-010-0168-0. Epub 2010 Aug 27.
To describe our experience in children hospitalized with the pandemic Influenza A (H1N1) from Northern India.
The retrospective case study was conducted at the Pediatric ward and Pediatric Intensive Care Unit (PICU) dedicated to the children (aged 18 years or younger) with influenza-like illness (ILI) with positive laboratory test results for pandemic H1N1 by reverse-transcriptase polymerase-chain-reaction assay.
Between August 2009 and January 2010, a total of 100 children were hospitalized with suspected 2009 H1N1 influenza with Category "C" as described by the Government of India. Twenty five patients were positive for H1N1 and 9 for seasonal influenza A. The most common presentation (H1N1 positive) was with fever (100%), cough (100%), coryza (52%), respiratory distress (88%), vomiting (28%) and diarrhea (16%). One child presented with hypernatremic dehydration and seizures (Serum sodium 174 meq/l). Of the H1N1 positive hospitalized children, 7 (28%) had respiratory failure and required PICU admission, 4 (16%) required mechanical ventilation, and 3 (12%) died. The major radiological findings were bilateral pulmonary infiltrates and consolidation. All patients were treated with oral Oseltamivir suspension or capsule as per appropriate weigh band and supportive care as required. Two deaths were caused by refractory hypoxemia and one by refractory shock.
The exact incidence of Pandemic 2009 H1N1 influenza on morbidity and mortality is difficult to calculate since only Category "C" patients were screened.
描述印度北部因大流行性甲型 H1N1 流感而住院的儿童的经验。
本回顾性病例研究在儿科病房和儿科重症监护病房（PICU）进行，研究对象为流感样疾病（ILI）伴有经逆转录酶聚合酶链反应检测呈阳性的大流行性 H1N1 流感的儿童（年龄在 18 岁或以下）。
2009 年 8 月至 2010 年 1 月，共有 100 名儿童因疑似 2009 年 H1N1 流感住院，印度政府将其归类为 C 类。25 例患者 H1N1 阳性，9 例季节性流感 A 阳性。最常见的表现（H1N1 阳性）是发热（100%）、咳嗽（100%）、鼻咽炎（52%）、呼吸窘迫（88%）、呕吐（28%）和腹泻（16%）。1 例患儿表现为高钠血症性脱水和惊厥（血清钠 174 mEq/L）。住院的 H1N1 阳性患儿中，7 例（28%）出现呼吸衰竭，需要转入 PICU，4 例（16%）需要机械通气，3 例（12%）死亡。主要的放射学发现是双侧肺浸润和实变。所有患者均根据适当的体重带给予口服奥司他韦混悬液或胶囊，并根据需要给予支持性治疗。2 例死亡是由于难治性低氧血症，1 例是由于难治性休克。
由于仅对 C 类患者进行了筛查，因此很难计算大流行性 2009 年 H1N1 流感对发病率和死亡率的确切影响。
