印度儿童中的甲型H1N1猪源流感。

Swine-origin influenza A (H1N1) in Indian children.

作者信息

Saha A, Jha N, Dubey N K, Gupta V K, Kalaivani M

机构信息

Department of Pediatrics, Postgraduate Institute of Medical Education & Research and Associated Dr Ram Manohar Lohia Hospital, New Delhi, India.

出版信息

Ann Trop Paediatr. 2010;30(1):51-5. doi: 10.1179/146532810X12637745452031.

DOI:10.1179/146532810X12637745452031

PMID:20196934

Abstract

BACKGROUND

Swine-origin influenza A H1N1 (S-OIV) has not been systematically studied in Indian children.

OBJECTIVES

To study the clinical characteristics, morbidity and mortality pattern in children with S-OIV infection.

METHODS

This prospective study was conducted during the 'containment phase' of the pandemic in New Delhi from 10 June to 5 August 2009. All children suspected of being infected by S-OIV were admitted to the isolation wards and clinically evaluated according to WHO guidelines. Nasal and throat swabs were collected immediately for real-time reverse transcriptase polymerase chain reaction (RT-PCR). Haemoglobin, total leucocyte and platelet counts and chest radiography were undertaken in all patients. Those who tested positive for S-OIV infection were treated with oseltamivir for 5 days in isolation wards.

RESULTS

Thirty-seven children fulfilled the inclusion criteria. Twenty-one tested positive for S-OIV by RT-PCR and 16 tested negative. Comparison of the clinical characteristics of the two groups showed that duration of cough was longer in children with S-OIV (p<0.03). Total leucocyte and lymphocyte counts were significantly less in the S-OIV group (p<0.001 and , 0.02, respectively). Oseltamivir-related gastritis was seen in 38% of children. All improved and were discharged.

CONCLUSION

S-OIV infection in Indian children had features similar to those of seasonal influenza. Lymphopenia is an important feature of S-OIV.

摘要

背景

甲型H1N1流感病毒（S-OIV）尚未在印度儿童中进行系统研究。

目的

研究感染S-OIV的儿童的临床特征、发病率和死亡率模式。

方法

这项前瞻性研究于2009年6月10日至8月5日在新德里大流行的“遏制阶段”进行。所有疑似感染S-OIV的儿童均被收入隔离病房，并根据世界卫生组织指南进行临床评估。立即采集鼻拭子和咽拭子进行实时逆转录聚合酶链反应（RT-PCR）检测。对所有患者进行血红蛋白、全血细胞计数和血小板计数以及胸部X线检查。那些S-OIV感染检测呈阳性的患者在隔离病房接受了5天的奥司他韦治疗。

结果

37名儿童符合纳入标准。21名儿童RT-PCR检测S-OIV呈阳性，16名呈阴性。两组临床特征比较显示，S-OIV感染儿童的咳嗽持续时间更长（p<0.03）。S-OIV组的全血细胞计数和淋巴细胞计数显著较低（分别为p<0.001和p<0.02）。38%的儿童出现了奥司他韦相关胃炎。所有患儿病情均好转并出院。