Comer John E
Sirius Analytical Instruments, Riverside, Unit 12 Forest Row Business Park, Forest Row, East Sussex, UK.
IDrugs. 2010 Sep;13(9):610-4.
SMi's fifth annual ADMET Conference, held in London, included topics covering new developments in the field of ADMET. This conference report highlights selected presentations on ADME optimization in drug discovery; targeting drugs to the brain; predicting bonds that might be attacked during metabolism; treating Caco-2 membranes with vinblastine to enhance P-glycoprotein interactions; predictive ADMET in hit-to-lead optimization; structure-based studies of ADMET targets; an accelerated process for integrated drug development; building hypotheses in lead selection and optimization; supersaturation effects; the prediction of drug-drug interactions; developing a mechanism-based pharmacokinetic/pharmacodynamic model; drug transporter assays in drug discovery; time-dependent inhibition screens in early drug discovery; the system-dependent inhibition of CYP enzymes; the integrating predictive toxicology framework OpenTox; high-content analysis for predictive cytotoxicity testing; and emerging in vitro toxicity assays.
SMi在伦敦举办的第五届年度药物吸收、分布、代谢、排泄及毒性（ADMET）会议涵盖了ADMET领域的新进展等主题。本会议报告重点介绍了药物发现中ADME优化方面的部分演讲内容；药物靶向大脑；预测代谢过程中可能被攻击的化学键；用长春碱处理Caco-2细胞膜以增强P-糖蛋白相互作用；从活性化合物到先导化合物优化过程中的预测性ADMET；基于结构的ADMET靶点研究；综合药物开发的加速流程；先导化合物选择与优化中的假设构建；过饱和效应；药物相互作用预测；建立基于机制的药代动力学/药效学模型；药物发现中的药物转运体检测；早期药物发现中的时间依赖性抑制筛选；CYP酶的系统依赖性抑制；整合预测毒理学框架OpenTox；用于预测细胞毒性测试的高内涵分析；以及新兴的体外毒性检测方法。
