Catauro M, Raucci M G, Ausanio G, Ambrosio L
Department of Mechanic and Aerospace Engineering, Second University of Naples, Aversa - Italy.
J Appl Biomater Biomech. 2007 Jan-Apr;5(1):41-8.
Novel organic-inorganic hybrid materials were synthesized by the sol-gel method from a multicomponent solution containing titanium butoxide, 6 weight % (wt%) or 12 wt% poly(ether-imide) (PEI), water and chloroform. The structure of the interpenetrating network is realized by hydrogen bonds between the Ti-OH group (H-donator) in the sol-gel intermediate species and the carboxylic group (H-acceptor) in the repeating units of the polymer. By Fourier transform infrared (FTIR) analysis the presence of hydrogen bonds between organic-inorganic components of the hybrid materials were proved. The morphology of the hybrid materials was studied by scanning electron microscopy (SEM). The structure of a molecular level dispersion was disclosed by an atomic force microscope (AFM), pore size distribution and surface measurements. The AFM and SEM analyzes confirmed that the PEI/TiO2 samples can be considered homogenous organic/inorganic hybrid materials because in both the compositions studied the average domains were less than 400 nm in size. The bioactivity of the synthesized hybrid materials was demonstrated by the formation of a layer of hydroxyapatite on the surface of the PEI/TiO2 samples soaked in a fluid simulating the composition of human blood plasma (SBF), demonstrated by SEM and energy dispersive spectroscopy (EDS) microscopy.
通过溶胶-凝胶法，由包含丁醇钛、6重量%（wt%）或12 wt%聚醚酰亚胺（PEI）、水和氯仿的多组分溶液合成了新型有机-无机杂化材料。互穿网络结构是通过溶胶-凝胶中间物种中的Ti-OH基团（氢供体）与聚合物重复单元中的羧基（氢受体）之间的氢键实现的。通过傅里叶变换红外（FTIR）分析，证明了杂化材料有机-无机组分之间存在氢键。通过扫描电子显微镜（SEM）研究了杂化材料的形态。通过原子力显微镜（AFM）、孔径分布和表面测量揭示了分子水平分散的结构。AFM和SEM分析证实，PEI/TiO₂样品可被视为均匀的有机/无机杂化材料，因为在所研究的两种组合物中，平均域尺寸均小于400 nm。通过扫描电子显微镜（SEM）和能量色散光谱（EDS）显微镜证明，浸泡在模拟人血浆成分（SBF）的流体中的PEI/TiO₂样品表面形成了一层羟基磷灰石，从而证明了合成杂化材料的生物活性。
