Department of Mechanical and Aerospace Engineering, Second University of Naples, Aversa - Italy.
J Appl Biomater Funct Mater. 2013 Dec 16;11(3):e172-9. doi: 10.5301/JABFM.2012.9256.
A novel organic/inorganic hybrid material, based on poly(ε-caprolactone) (PCL) and silica (SiO₂), were synthesized by the sol-gel method. An anti-inflammatory agent (indomethacin) was incorporated into the hybrid material to verify its local controlled drug delivery system.
The structure of the interpenetrating network was investigated by Fourier transform infrared spectroscopy. The morphology of the materials was studied by scanning electron microscopy. The structure of a molecular level dispersion was disclosed by atomic force microscopy. The bioactivity of the synthesized hybrid materials was revealed by the formation of a layer of hydroxyapatite on the surface of samples soaked in a simulated body fluid (SBF). Release kinetics in SBF were subsequently investigated. The amount of drug released was detected by UV-VIS spectroscopy.
Pure anti-inflammatory agent exhibited linear release with time; in contrast, sol-gel silica entrapped drugs were released with a logarithmic time dependence starting with an initial burst effect followed by a gradual decrease.
SiO₂/PCL (3, 6, 9 and 12 %wt) materials, prepared via sol-gel process, are organic/inorganic hybrid and bioactive materials. All the materials showed a good release and therefore could be used as drug delivery system.
采用溶胶-凝胶法合成了一种新型有机/无机杂化材料，该材料以聚己内酯（PCL）和二氧化硅（SiO₂）为基础。将一种抗炎剂（吲哚美辛）掺入杂化材料中，以验证其局部控释药物传递系统。
通过傅里叶变换红外光谱研究了互穿网络的结构。通过扫描电子显微镜研究了材料的形态。原子力显微镜揭示了分子水平分散的结构。将合成的杂化材料浸泡在模拟体液（SBF）中，通过在样品表面形成一层羟基磷灰石来揭示其生物活性。随后在 SBF 中研究了释放动力学。通过紫外可见光谱检测释放的药物量。
纯抗炎剂随时间呈线性释放；相比之下，溶胶-凝胶二氧化硅包埋药物的释放具有对数时间依赖性，起始时具有初始突释效应，随后逐渐减少。
通过溶胶-凝胶法制备的 SiO₂/PCL（3、6、9 和 12%wt）材料是有机/无机杂化和生物活性材料。所有材料均表现出良好的释放性能，因此可作为药物传递系统。
