Ono T, Yamamoto S, Kurishita A, Yamamoto K, Yamamoto Y, Ujeno Y, Sagisaka K, Fukui Y, Miyamoto M, Tawa R
Department of Radiation Research, Tohoku University School of Medicine, Sendai, Japan.
Mutat Res. 1990 Sep-Nov;237(5-6):239-46. doi: 10.1016/0921-8734(90)90005-c.
Age-associated changes in DNA methylation of the c-myc gene in liver were compared between humans and mice which have large differences in aging rate. Although the overall methylation profiles of the gene and their age-related changes were found to be similar, the rate of change was much slower in humans than in mice. It suggests that the age-associated alteration of c-myc gene methylation is closely related to biological aging rather than to chronological aging.
在衰老速度差异很大的人类和小鼠之间，比较了肝脏中c-myc基因DNA甲基化的年龄相关变化。尽管发现该基因的整体甲基化图谱及其与年龄相关的变化相似，但人类的变化速度比小鼠慢得多。这表明c-myc基因甲基化的年龄相关改变与生物衰老密切相关，而非与时间衰老相关。
