Lishmanov Iu B, Maslov L N, Maslova L V, Krivonogov N G
Patol Fiziol Eksp Ter. 1990 Jul-Aug(4):7-9.
Clinical studies showed that short-term "physiological" stress (bicycle ergometry) did not cause increase of the blood plasma enkephalin content. Moderate-term (60-minute) stress, according to O. Desiderato, causes a rise of the blood enkephalin level in rats. It is supposed that such a reaction of the opioid system is characteristic of borderline conditions between normal and pathological states in stress. Severe "pathological" stress (myocardial infarction, experimental coronary occlusion, 6-hour stress after O. Desiderato) in rats led to a decrease of the concentration of enkephalins in the blood and disorders of their secretion and storage in the adrenals. It is suggested that changes of the activity of the opioid system are a predictor of the transition of a "physiological" stress to a "pathological" stress.
临床研究表明，短期“生理性”应激（自行车测力计运动）不会导致血浆脑啡肽含量增加。根据O. 德西德拉托的研究，中期（60分钟）应激会使大鼠血液中的脑啡肽水平升高。据推测，阿片系统的这种反应是应激状态下正常与病理状态之间临界情况的特征。大鼠的严重“病理性”应激（心肌梗死、实验性冠状动脉闭塞、O. 德西德拉托之后的6小时应激）导致血液中脑啡肽浓度降低，以及它们在肾上腺中的分泌和储存紊乱。有人提出，阿片系统活性的变化是“生理性”应激向“病理性”应激转变的一个预测指标。
