Beijing Institute of Pharmacology and Toxicology, 27 Taiping Road, Beijing 100850, China.
Pharmacol Biochem Behav. 2010 Dec;97(2):256-61. doi: 10.1016/j.pbb.2010.08.007. Epub 2010 Aug 27.
The effect of agmatine on memory formation in morphine-treated mice on the step-down inhibitory avoidance test was examined. Pre-training and pre-test administration of agmatine (5, 10 and 20mg/kg, s.c.) facilitated memory formation and retrieval while post-training administration of agmatine (5, 10 and 20mg/kg, s.c.) had no effect on memory consolidation. Idazoxan (5mg/kg, i.p.) inhibited the effect of agmatine on memory formation and retrieval. Pre-training administration of morphine (1.25, 2.5 and 5mg/kg, s.c.) impaired memory formation while post-training and pre-test administration of morphine (1.25, 2.5 and 5mg/kg, s.c.) had no effect on memory consolidation and retrieval. Pre-training agmatine treatment reversed the impairment of morphine on memory formation. Moreover, pre-test administration of agmatine inhibited morphine-induced amnesia. Pre-training and pre-test idazoxan (5mg/kg, i.p.) treatment inhibited the effect of agmatine on morphine induced memory impairment. In conclusion, agmatine inhibited morphine-induced memory impairment on the mice step-down inhibitory avoidance test. The mechanism was exerted, at least in part, through activation of imidazoline receptors.
胍丁胺对吗啡处理小鼠在跳下抑制回避测试中记忆形成的影响进行了研究。胍丁胺（5、10 和 20mg/kg，sc）的预训练和预测试给药促进了记忆的形成和提取，而胍丁胺（5、10 和 20mg/kg，sc）的训练后给药对记忆巩固没有影响。伊达唑（5mg/kg，ip）抑制了胍丁胺对记忆形成和提取的影响。吗啡（1.25、2.5 和 5mg/kg，sc）的预训练给药损害了记忆的形成，而吗啡（1.25、2.5 和 5mg/kg，sc）的训练后和预测试给药对记忆的巩固和提取没有影响。胍丁胺的预训练给药逆转了吗啡对记忆形成的损害。此外，胍丁胺的预测试给药抑制了吗啡引起的健忘症。预训练和预测试伊达唑（5mg/kg，ip）处理抑制了胍丁胺对吗啡引起的记忆损伤的作用。总之，胍丁胺抑制了吗啡在小鼠跳下抑制回避测试中引起的记忆损伤。其机制至少部分是通过激活咪唑啉受体发挥作用的。
