O Kadry Mai, Ali Hanaa Mahmoud
Therapeutic Chemistry Department, National Research Centre, El Buhouth St., Dokki, 12622, Egypt.
Department of Genetics & Cytology, National Research Centre, Dokki, 12622, Egypt.
Future Sci OA. 2024 May 20;10(1):FSO911. doi: 10.2144/fsoa-2023-0117. eCollection 2024.
The fundamental pathophysiology of ischemic-hypoxia is oxygen depletion. Fischer's ratio is essential for monitoring hypoxia intensity. the current study highlighted the prophylactic role of sophoretin (QRC) and/or melatonin (MLN) versus sodium nitrite (SN) brain hypoxia. Prophylactic treatment with sophoretin and MLN, was preceded with hypoxia-induction via sodium nitrite (60 mg/kg, S.C.). SN decreased hemoglobin (Hb), elevated , HSP-70, IL-6 and TNF-α. Sophoretin and/or MLN restored the ameliorated inflammatory biomarkers, modulated norepinephrine, dopamine, serotonin and gamma-aminobutyric acid (GABA). Similarly, single-cell gel electrophoresis (SCGE or COMET) DNA damage assay confirmed this finding. Treatment via sophoretin and MLN was the most effective therapy for improving sodium nitrite-induced brain injury.
缺血缺氧的基本病理生理学是氧耗竭。费舍尔比率对于监测缺氧强度至关重要。当前研究强调了槐果碱（QRC）和/或褪黑素（MLN）相对于亚硝酸钠（SN）对脑缺氧的预防作用。在通过亚硝酸钠（60mg/kg，皮下注射）进行缺氧诱导之前，先使用槐果碱和MLN进行预防性治疗。SN降低了血红蛋白（Hb），升高了 ，热休克蛋白70（HSP-70）、白细胞介素6（IL-6）和肿瘤坏死因子α（TNF-α）。槐果碱和/或MLN恢复了改善的炎症生物标志物，调节了去甲肾上腺素、多巴胺、5-羟色胺和γ-氨基丁酸（GABA）。同样，单细胞凝胶电泳（SCGE或彗星试验）DNA损伤测定证实了这一发现。通过槐果碱和MLN进行治疗是改善亚硝酸钠诱导的脑损伤的最有效疗法。
