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2-、3- 和 4-(1-氧代-1H-2,3-二氢异吲哚-2-基)苯甲酸及其相应的有机锡羧酸盐:合成、表征、荧光和生物活性。

2-, 3-, and 4-(1-Oxo-1H-2,3-dihydroisoindol-2-yl)benzoic acids and their corresponding organotin carboxylates: synthesis, characterization, fluorescent, and biological activities.

机构信息

College of Chemistry and Chemical Engineering, Hunan University, Changsha, Hunan 410082, China.

出版信息

Bioorg Med Chem Lett. 2010 Oct 1;20(19):5649-52. doi: 10.1016/j.bmcl.2010.08.034. Epub 2010 Aug 11.

Abstract

Three novel organotin complexes with general formula Sn(OH)(bz)(2)L (bz = benzyl, HL = 2-, 3-, or 4-(1-oxo-1H-2,3-dihydroisoindol-2-yl)benzoic acid) and one of their ligands were prepared and characterized. In vitro antifungal and antibacterial activities of these complexes and ligands were investigated with the representative strains of Candida albicans, Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa. Their fluorescence properties have also been discussed.

摘要

三种新型有机锡配合物,通式为 Sn(OH)(bz)(2)L(bz = 苄基,HL = 2-、3- 或 4-(1-氧代-1H-2,3-二氢异吲哚-2-基)苯甲酸)及其一种配体被制备并进行了表征。用代表性的白色念珠菌、金黄色葡萄球菌、大肠杆菌和铜绿假单胞菌菌株对这些配合物和配体的体外抗真菌和抗菌活性进行了研究。还讨论了它们的荧光性质。

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