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咔唑衍生物的合成、抗菌和抗真菌活性。

Synthesis, antibacterial and antifungal activities of some carbazole derivatives.

机构信息

School of Chemistry and Chemical Engineering, Southwest University, Chongqing, China.

出版信息

Bioorg Med Chem Lett. 2010 Mar 15;20(6):1881-4. doi: 10.1016/j.bmcl.2010.01.159. Epub 2010 Feb 4.

Abstract

A series of N-substituted carbazole derivatives were synthesized and evaluated for antibacterial and antifungal activities against Staphylococcus aureus, methicillin-resistant Staphylococcus aureus (MRSA), Bacillus subtilis, Escherichia coli, Pseudomonas aeruginosa, Bacillus proteus, Candida albicans and Aspergillus fumigatus by two fold serial dilution technique. Some of the synthesized compounds displayed comparable or even better antibacterial and antifungal activities than reference drugs fluconazole, chloramphenicol and norfloxacin against tested strains.

摘要

合成了一系列 N-取代咔唑衍生物,并通过二倍稀释法评估了它们对金黄色葡萄球菌、耐甲氧西林金黄色葡萄球菌(MRSA)、枯草芽孢杆菌、大肠杆菌、铜绿假单胞菌、变形杆菌、白色念珠菌和烟曲霉的抗菌和抗真菌活性。一些合成化合物对测试菌株的抗菌和抗真菌活性与氟康唑、氯霉素和诺氟沙星等参考药物相当,甚至更好。

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