State Key Laboratory of Biocontrol, Key Laboratory of Gene Engineering of the Ministry of Education, Sun Yat-sen University, Guangzhou, People's Republic of China.
RNA. 2010 Oct;16(10):1889-901. doi: 10.1261/rna.2226910. Epub 2010 Aug 26.
Imprinted noncoding RNAs (ncRNAs) are expressed mono-allelically in a parent-of-origin-dependent manner, which is mainly evident in mammals. Lying at a crossroad between imprinted genes and ncRNAs, imprinted ncRNAs show distinct features. They are likely to function in nontraditional ways compared to non-imprinted ncRNAs, and are much more responsible for the mechanism of genomic imprinting compared to imprinted protein-coding genes. An increasing number of human diseases have been shown to be related to abnormalities in imprinted ncRNAs. Due to their functional importance, many studies focusing on imprinted ncRNAs have been published in recent years; however, there is no systematic collection or description of imprinted ncRNAs and the rapidly growing knowledge is scattered in various places. Here, we describe a new database, ncRNAimprint, which serves as a comprehensive resource center for mammalian imprinted ncRNAs. A catalog of imprinted ncRNAs, including snoRNAs, microRNAs, piRNAs, siRNAs, antisense ncRNAs, and mRNA-like ncRNAs, was annotated in detail using information extracted from relevant literature and databases. Comprehensive collections of imprinted ncRNA-related diseases, imprinting control regions (ICRs), and imprinted regions were manually compiled to provide resources for current research focusing on imprinted ncRNAs. Small RNA deep sequencing reads that fully matched within imprinted regions were also included to offer useful evidence in detecting novel imprinted ncRNAs and to aid in analyzing expression patterns of known imprinted ncRNAs. A search page including four effective search forms and two graphical browsers was created for rapid retrieval and visualization of these data. The imprinted ncRNA database is freely accessible at http://rnaqueen.sysu.edu.cn/ncRNAimprint.
印迹非编码 RNA（ncRNAs）以亲本来源依赖的单等位基因方式表达，这主要在哺乳动物中明显。位于印迹基因和 ncRNAs 的交叉路口，印迹 ncRNAs 表现出独特的特征。与非印迹 ncRNAs 相比，它们可能以非传统的方式发挥作用，并且与印迹蛋白编码基因相比，它们对基因组印迹的机制更负责。越来越多的人类疾病已被证明与印迹 ncRNAs 的异常有关。由于其功能重要性，近年来发表了许多关于印迹 ncRNAs 的研究；然而，没有对印迹 ncRNAs 进行系统的收集或描述，并且快速增长的知识分散在各个地方。在这里，我们描述了一个新的数据库 ncRNAimprint，它是哺乳动物印迹 ncRNAs 的综合资源中心。一个包括 snoRNAs、miRNAs、piRNAs、siRNAs、反义 ncRNAs 和 mRNA 样 ncRNAs 的印迹 ncRNAs 目录，使用从相关文献和数据库中提取的信息进行了详细注释。精心编制了印迹 ncRNA 相关疾病、印迹控制区（ICRs）和印迹区域的综合收集，为当前专注于印迹 ncRNAs 的研究提供资源。还包括完全匹配印迹区域内的小 RNA 深度测序读数，为检测新的印迹 ncRNAs 提供有用的证据，并有助于分析已知印迹 ncRNAs 的表达模式。创建了一个包含四个有效搜索表单和两个图形浏览器的搜索页面，用于快速检索和可视化这些数据。印迹 ncRNA 数据库可在 http://rnaqueen.sysu.edu.cn/ncRNAimprint 免费获取。
