Center for Biomolecular Science and Engineering, School of Engineering, University of California Santa Cruz, Santa Cruz, CA 95064, USA.
Nucleic Acids Res. 2010 Jan;38(Database issue):D613-9. doi: 10.1093/nar/gkp939. Epub 2009 Nov 11.
The University of California, Santa Cruz (UCSC) Genome Browser website (http://genome.ucsc.edu/) provides a large database of publicly available sequence and annotation data along with an integrated tool set for examining and comparing the genomes of organisms, aligning sequence to genomes, and displaying and sharing users' own annotation data. As of September 2009, genomic sequence and a basic set of annotation 'tracks' are provided for 47 organisms, including 14 mammals, 10 non-mammal vertebrates, 3 invertebrate deuterostomes, 13 insects, 6 worms and a yeast. New data highlights this year include an updated human genome browser, a 44-species multiple sequence alignment track, improved variation and phenotype tracks and 16 new genome-wide ENCODE tracks. New features include drag-and-zoom navigation, a Wiki track for user-added annotations, new custom track formats for large datasets (bigBed and bigWig), a new multiple alignment output tool, links to variation and protein structure tools, in silico PCR utility enhancements, and improved track configuration tools.
加州大学圣克鲁兹分校（UCSC）基因组浏览器网站（http://genome.ucsc.edu/）提供了一个大型的公共序列和注释数据库，以及一套集成的工具集，用于检查和比较生物体的基因组、将序列与基因组对齐，以及显示和共享用户自己的注释数据。截至 2009 年 9 月，基因组序列和基本的注释 '轨道' 提供了 47 个生物体，包括 14 种哺乳动物、10 种非哺乳动物脊椎动物、3 种后生动物、13 种昆虫、6 种蠕虫和一种酵母。今年的新数据亮点包括更新的人类基因组浏览器、44 个物种的多序列比对轨道、改进的变异和表型轨道以及 16 个新的全基因组 ENCODE 轨道。新功能包括拖放缩放导航、用户添加注释的 Wiki 轨道、用于大型数据集的新自定义轨道格式（bigBed 和 bigWig）、新的多序列比对输出工具、到变异和蛋白质结构工具的链接、虚拟 PCR 实用程序增强功能以及改进的轨道配置工具。
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