Institute of General Practice, Hannover Medical School, Germany.
Aging Clin Exp Res. 2011 Aug;23(4):288-95. doi: 10.1007/BF03337755. Epub 2010 Aug 27.
The hypothesis of increased cardiovascular risk contributing to chronic dizziness has been discussed controversially so far. We investigated older patients suffering from acute (<6 months), chronic (≥ 6 months) or no dizziness, in terms of their cardiovascular risk and other impairments.
A cross-sectional three-group comparison of 257 patients (65+) presenting at family medicine surgeries in Germany was performed. Measures of cardiovascular risk, including overall scores, scores of quality of life (SF-12), activities of daily living (ADL), depression (GDS), dizziness handicap (DHI) and patients' needs (DiNA), as well as comorbidity and medication, were compared in univariate and multivariate logistic regression analysis.
In univariate analysis, systolic and diastolic blood pressure were significantly lower in the dizziness groups. The overall cardiovascular risk was not increased in dizzy patients. Anxiety was strongly associated with dizziness, whereas other associations were of marginal importance. In multivariate analysis, age (OR 1.10, 95% CI 1.03-1.17), female gender (OR 2.07, 95% CI 1.01-4.26) and anxiety (OR 2.50, 95% CI 1.03-6.05) were associated with acute dizziness, whereas only female gender was significant in chronic dizziness (OR 1.96, 95% CI 1.02- 3.75). Comparing all dizzy patients with the non-dizzy group, lower systolic blood pressure was also significantly associated with dizziness.
Results from our sample suggest that low systolic blood pressure is more important for dizziness in older patients than increased cardiovascular risk. Acute-onset and long-term dizzy patients were comparable in many aspects, which makes this classification less clinically important.
目前,人们对于心血管风险增加导致慢性头晕的假说仍存在争议。我们对患有急性(<6 个月)、慢性(≥6 个月)或无头晕的老年患者进行了心血管风险及其他障碍的研究。
我们对德国家庭医生诊所的 257 名(≥65 岁)患者进行了横断面三组比较。采用单变量和多变量逻辑回归分析比较了心血管风险的各项指标,包括整体评分、生活质量评分(SF-12)、日常生活活动(ADL)、抑郁评分(GDS)、头晕障碍评分(DHI)和患者需求评分(DiNA)、共病和用药情况。
在单变量分析中,头晕组的收缩压和舒张压明显较低。头晕患者的总体心血管风险并未增加。焦虑与头晕强烈相关,而其他相关性则具有边缘重要性。在多变量分析中,年龄(OR 1.10,95%CI 1.03-1.17)、女性(OR 2.07,95%CI 1.01-4.26)和焦虑(OR 2.50,95%CI 1.03-6.05)与急性头晕相关,而慢性头晕仅与女性相关(OR 1.96,95%CI 1.02-3.75)。与非头晕组相比,所有头晕患者的收缩压较低与头晕也具有显著相关性。
我们的样本结果表明,对于老年患者来说,收缩压降低比心血管风险增加更与头晕相关。急性和慢性头晕患者在许多方面具有可比性,这使得这种分类在临床上的重要性降低。