Williams David R, Fu Liangfeng
Department of Chemistry, Indiana University, 800 East Kirkwood Avenue, Bloomington, IN 47405-7102, USA.
Synlett. 2010 Jul 1;2010(11):1641-1646. doi: 10.1055/s-0029-1220128.
Suzuki and Stille cross-coupling reactions are surveyed for site-selective C-4 and C-5 elaboration of 2-(phenylsulfonyl)-1,3-oxazole derivatives. Conditions for mild reductive desulfonylations provide for direct incorporation of the intact oxazole heterocycle through bonding at C-4 and C-5.
对铃木反应和施蒂勒交叉偶联反应进行了研究,以用于对2-(苯磺酰基)-1,3-恶唑衍生物进行位点选择性的C-4和C-5修饰。温和的还原脱磺酰化条件使得完整的恶唑杂环能够通过在C-4和C-5处的键合直接引入。